Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19

Boxuan Yu; Ligen Yu; Daniel J. Klionsky

doi:10.1016/j.mehy.2021.110668

Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19

Boxuan Yu^*, Ligen Yu, Daniel J. Klionsky

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

10 Citations (Scopus)

Abstract

The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.

Original language	English
Article number	110668
Journal	Medical Hypotheses
Volume	155
DOIs	https://doi.org/10.1016/j.mehy.2021.110668
Publication status	Published - Oct 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

ASJC Scopus Subject Areas

General Medicine

Keywords

COVID-19
Cytokine storm
Hyperinflammation
Immune system
Nutrition acquisition
Overnutrition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mehy.2021.110668

Cite this

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title = "Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19",

abstract = "The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.",

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year = "2021",

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doi = "10.1016/j.mehy.2021.110668",

language = "English",

volume = "155",

journal = "Medical Hypotheses",

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AU - Yu, Boxuan

AU - Yu, Ligen

AU - Klionsky, Daniel J.

PY - 2021/10

Y1 - 2021/10

N2 - The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.

AB - The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.

KW - COVID-19

KW - Cytokine storm

KW - Hyperinflammation

KW - Immune system

KW - Nutrition acquisition

KW - Overnutrition

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M3 - Letter

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M1 - 110668

ER -

Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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