TY - JOUR
T1 - Optical coherence tomography angiography enables visualization of microvascular patterns in chronic venous insufficiency
AU - Rotunno, Giulia
AU - Deinsberger, Julia
AU - Meiburger, Kristen M.
AU - Krainz, Lisa
AU - Bugyi, Lukasz
AU - Hacker, Valentin
AU - Haindl, Richard
AU - Leitgeb, Rainer
AU - Sinz, Christoph
AU - Schmetterer, Leopold
AU - Drexler, Wolfgang
AU - Weber, Benedikt
AU - Liu, Mengyang
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/11/15
Y1 - 2024/11/15
N2 - Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature. The study enlisted 66 subjects, including 53 CVI patients spanning all clinical-etiology-anatomic-pathophysiologic (CEAP) C stages and 13 healthy controls. The high spatial resolution OCTA system used was specifically designed for skin imaging. Significant microangiographic pattern variations emerged, both in qualitative and quantitative terms. OCTA provided valuable insights into cutaneous microvascular changes among different CVI stages. Thereby, OCTA may enable the selection of patient populations at risk for disease progression in the future.
AB - Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature. The study enlisted 66 subjects, including 53 CVI patients spanning all clinical-etiology-anatomic-pathophysiologic (CEAP) C stages and 13 healthy controls. The high spatial resolution OCTA system used was specifically designed for skin imaging. Significant microangiographic pattern variations emerged, both in qualitative and quantitative terms. OCTA provided valuable insights into cutaneous microvascular changes among different CVI stages. Thereby, OCTA may enable the selection of patient populations at risk for disease progression in the future.
KW - Health sciences
KW - Optical imaging
KW - Vascular anatomy
UR - http://www.scopus.com/inward/record.url?scp=85207747081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85207747081&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.110998
DO - 10.1016/j.isci.2024.110998
M3 - Article
AN - SCOPUS:85207747081
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 11
M1 - 110998
ER -
