Optical coherence tomography angiography for the anterior segment

Wen Di Lee, Kavya Devarajan, Jacqueline Chua, Leopold Schmetterer, Jodhbir S. Mehta, Marcus Ang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)

Abstract

Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. However, conventional OCTA systems are typically designed and optimized for the posterior segment of the eye, and thus using OCTA for anterior segment imaging can present several difficulties and limitations. In this review, we summarized the recent developments and clinical applications in anterior segment OCTA (AS-OCTA) imaging, such as for the cornea, iris, sclera and conjunctiva. We also compared commercially available OCTA systems, discussed the limitations of adapting current OCTA technology for the anterior segment imaging, and proposed possible future directions for AS-OCTA systems. AS-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies, pre-operative surgical planning, assessment of new anti-angiogenic therapeutics or evaluation of limbal stem cell deficiency. With further development, OCTA for anterior segment imaging in the clinics may become common in the near future.

Original languageEnglish
Article number4
JournalEye and Vision
Volume6
Issue number1
DOIs
Publication statusPublished - Dec 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

ASJC Scopus Subject Areas

  • Ophthalmology
  • Health Professions (miscellaneous)

Keywords

  • Anterior segment
  • Cornea
  • Iris
  • Optical coherence tomography angiography
  • Vascularisation

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