Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents

Bingyao Tan; Huakun Li; Yueming Zhuo; Le Han; Rajeshkumar Mupparapu; Veluchamy Amutha Barathi; Daniel Palanker; Leopold Schmetterer; Tong Ling

doi:10.1117/12.3003655

Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents

Bingyao Tan, Huakun Li, Yueming Zhuo, Le Han, Rajeshkumar Mupparapu, Veluchamy Amutha Barathi, Daniel Palanker^*, Leopold Schmetterer^*, Tong Ling^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Small animals, such as rodents, are attractive options for investigating the intrinsic process of retinal degeneration. In this study, we used phase-sensitive optical coherence tomography to explore the comprehensive dynamics of rats’ outer retinas in response to visual stimuli. By calculating the temporal phase difference between different outer retinal bands, we revealed highly reproducible retinal dynamics, on the order of tens of nanometers, related to different parts of the outer retina. Our approach may pave the way for preclinical optoretinography study in small animals, facilitating clinical translations for the early detection of neurodegenerative diseases.

Original language	English
Title of host publication	Ophthalmic Technologies XXXIV
Editors	Daniel X. Hammer, Kostadinka Bizheva, Georg Schuele
Publisher	SPIE
ISBN (Electronic)	9781510669079
DOIs	https://doi.org/10.1117/12.3003655
Publication status	Published - 2024
Externally published	Yes
Event	Ophthalmic Technologies XXXIV 2024 - San Francisco, United States Duration: Jan 27 2024 → Jan 28 2024

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12824
ISSN (Print)	1605-7422

Conference

Conference	Ophthalmic Technologies XXXIV 2024
Country/Territory	United States
City	San Francisco
Period	1/27/24 → 1/28/24

Bibliographical note

Publisher Copyright:
© 2024 SPIE.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Keywords

functional imaging
ocular imaging
optical coherence tomography
Optoretinography
rodent
unsupervised learning

Access to Document

10.1117/12.3003655

Cite this

Tan, B., Li, H., Zhuo, Y., Han, L., Mupparapu, R., Barathi, V. A., Palanker, D., Schmetterer, L., & Ling, T. (2024). Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents. In D. X. Hammer, K. Bizheva, & G. Schuele (Eds.), Ophthalmic Technologies XXXIV Article 1282405 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12824). SPIE. https://doi.org/10.1117/12.3003655

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title = "Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents",

abstract = "Small animals, such as rodents, are attractive options for investigating the intrinsic process of retinal degeneration. In this study, we used phase-sensitive optical coherence tomography to explore the comprehensive dynamics of rats{\textquoteright} outer retinas in response to visual stimuli. By calculating the temporal phase difference between different outer retinal bands, we revealed highly reproducible retinal dynamics, on the order of tens of nanometers, related to different parts of the outer retina. Our approach may pave the way for preclinical optoretinography study in small animals, facilitating clinical translations for the early detection of neurodegenerative diseases.",

keywords = "functional imaging, ocular imaging, optical coherence tomography, Optoretinography, rodent, unsupervised learning",

author = "Bingyao Tan and Huakun Li and Yueming Zhuo and Le Han and Rajeshkumar Mupparapu and Barathi, {Veluchamy Amutha} and Daniel Palanker and Leopold Schmetterer and Tong Ling",

note = "Publisher Copyright: {\textcopyright} 2024 SPIE.; Ophthalmic Technologies XXXIV 2024 ; Conference date: 27-01-2024 Through 28-01-2024",

year = "2024",

doi = "10.1117/12.3003655",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Hammer, {Daniel X.} and Kostadinka Bizheva and Georg Schuele",

booktitle = "Ophthalmic Technologies XXXIV",

address = "United States",

}

Tan, B, Li, H, Zhuo, Y, Han, L, Mupparapu, R, Barathi, VA, Palanker, D, Schmetterer, L & Ling, T 2024, Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents. in DX Hammer, K Bizheva & G Schuele (eds), Ophthalmic Technologies XXXIV., 1282405, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12824, SPIE, Ophthalmic Technologies XXXIV 2024, San Francisco, United States, 1/27/24. https://doi.org/10.1117/12.3003655

Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents. / Tan, Bingyao; Li, Huakun; Zhuo, Yueming et al.
Ophthalmic Technologies XXXIV. ed. / Daniel X. Hammer; Kostadinka Bizheva; Georg Schuele. SPIE, 2024. 1282405 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12824).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Tan, Bingyao

AU - Li, Huakun

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AU - Han, Le

AU - Mupparapu, Rajeshkumar

AU - Barathi, Veluchamy Amutha

AU - Palanker, Daniel

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AU - Ling, Tong

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AB - Small animals, such as rodents, are attractive options for investigating the intrinsic process of retinal degeneration. In this study, we used phase-sensitive optical coherence tomography to explore the comprehensive dynamics of rats’ outer retinas in response to visual stimuli. By calculating the temporal phase difference between different outer retinal bands, we revealed highly reproducible retinal dynamics, on the order of tens of nanometers, related to different parts of the outer retina. Our approach may pave the way for preclinical optoretinography study in small animals, facilitating clinical translations for the early detection of neurodegenerative diseases.

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KW - ocular imaging

KW - optical coherence tomography

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Optoretinography reveals comprehensive nanoscopic dynamics of the outer retina in rodents

Abstract

Publication series

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Bibliographical note

ASJC Scopus Subject Areas

Keywords

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