Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Kiat Hwa Chan; Weng Kee Leong; Gerard Jaouen; Laurence Leclerq; Siden Top; Anne Vessières

doi:10.1016/j.jorganchem.2005.08.041

Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Kiat Hwa Chan, Weng Kee Leong^*, Gerard Jaouen, Laurence Leclerq, Siden Top, Anne Vessières

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Simple organometallic cluster analogues of tamoxifen containing triosmium or dicobalt carbonyl fragments have been prepared. Attempts at elaboration of these towards the tamoxifen skeleton were hampered by sensitivity of the cluster-ligand linkage towards the McMurry coupling conditions. Preliminary biological tests on various substrates indicate that the transition metal carbonyl fragment increases lipophilicity dramatically and reduces affinity for the estrogen receptor.

Original language	English
Pages (from-to)	9-19
Number of pages	11
Journal	Journal of Organometallic Chemistry
Volume	691
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jorganchem.2005.08.041
Publication status	Published - Jan 1 2006
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

Keywords

Cluster
Cobalt
Osmium
Tamoxifen

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10.1016/j.jorganchem.2005.08.041

Cite this

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T2 - Synthesis and biochemical assay

AU - Chan, Kiat Hwa

AU - Leong, Weng Kee

AU - Jaouen, Gerard

AU - Leclerq, Laurence

AU - Top, Siden

AU - Vessières, Anne

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Simple organometallic cluster analogues of tamoxifen containing triosmium or dicobalt carbonyl fragments have been prepared. Attempts at elaboration of these towards the tamoxifen skeleton were hampered by sensitivity of the cluster-ligand linkage towards the McMurry coupling conditions. Preliminary biological tests on various substrates indicate that the transition metal carbonyl fragment increases lipophilicity dramatically and reduces affinity for the estrogen receptor.

AB - Simple organometallic cluster analogues of tamoxifen containing triosmium or dicobalt carbonyl fragments have been prepared. Attempts at elaboration of these towards the tamoxifen skeleton were hampered by sensitivity of the cluster-ligand linkage towards the McMurry coupling conditions. Preliminary biological tests on various substrates indicate that the transition metal carbonyl fragment increases lipophilicity dramatically and reduces affinity for the estrogen receptor.

KW - Cluster

KW - Cobalt

KW - Osmium

KW - Tamoxifen

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JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

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ER -

Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Abstract

ASJC Scopus Subject Areas

Keywords

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