Orthogonal synthesis of isoindole and isoquinoline derivatives from organic azides

Benjamin Wei Qiang Hui; Shunsuke Chiba

doi:10.1021/ol802816k

Orthogonal synthesis of isoindole and isoquinoline derivatives from organic azides

Benjamin Wei Qiang Hui^*, Shunsuke Chiba

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

(Chemical Equation Presented) α-Azido carbonyl compounds bearing a 2-alkenylaryl moiety at the α-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddrtion of azides onto alkenes and fcrelectrocyclization of N-H imine intermediates, respectively.

Original language	English
Pages (from-to)	729-732
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1021/ol802816k
Publication status	Published - Feb 5 2009
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol802816k

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abstract = "(Chemical Equation Presented) α-Azido carbonyl compounds bearing a 2-alkenylaryl moiety at the α-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddrtion of azides onto alkenes and fcrelectrocyclization of N-H imine intermediates, respectively.",

author = "Hui, {Benjamin Wei Qiang} and Shunsuke Chiba",

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N2 - (Chemical Equation Presented) α-Azido carbonyl compounds bearing a 2-alkenylaryl moiety at the α-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddrtion of azides onto alkenes and fcrelectrocyclization of N-H imine intermediates, respectively.

AB - (Chemical Equation Presented) α-Azido carbonyl compounds bearing a 2-alkenylaryl moiety at the α-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddrtion of azides onto alkenes and fcrelectrocyclization of N-H imine intermediates, respectively.

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Orthogonal synthesis of isoindole and isoquinoline derivatives from organic azides

Abstract

ASJC Scopus Subject Areas

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