Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Benhui Hu; Wenxiong Shi; Yun Long Wu; Wan Ru Leow; Pingqiang Cai; Shuzhou Li; Xiaodong Chen

doi:10.1002/adma.201402489

Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Benhui Hu, Wenxiong Shi, Yun Long Wu, Wan Ru Leow, Pingqiang Cai, Shuzhou Li^*, Xiaodong Chen

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell-matrix adhesion and cell-cell adhesion. Decreasing the cell-matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.

Original language	English
Pages (from-to)	5786-5793
Number of pages	8
Journal	Advanced Materials
Volume	26
Issue number	33
DOIs	https://doi.org/10.1002/adma.201402489
Publication status	Published - Sept 3 2014
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Keywords

cell-matrix anchorage
multicellular behavior
polymer matrix
rigidity
topography

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10.1002/adma.201402489

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AU - Hu, Benhui

AU - Shi, Wenxiong

AU - Wu, Yun Long

AU - Leow, Wan Ru

AU - Cai, Pingqiang

AU - Li, Shuzhou

AU - Chen, Xiaodong

PY - 2014/9/3

Y1 - 2014/9/3

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AB - Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell-matrix adhesion and cell-cell adhesion. Decreasing the cell-matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.

KW - cell-matrix anchorage

KW - multicellular behavior

KW - polymer matrix

KW - rigidity

KW - topography

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Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

Abstract

ASJC Scopus Subject Areas

Keywords

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