Osmium carbonyl clusters: A new class of apoptosis inducing agents

Kien Voon Kong; Weng Kee Leong; Swee Phyaw Ng; Thanh Hung Nguyen; Lina H.K. Lim

doi:10.1002/cmdc.200800069

Osmium carbonyl clusters: A new class of apoptosis inducing agents

Kien Voon Kong, Weng Kee Leong, Swee Phyaw Ng, Thanh Hung Nguyen, Lina H.K. Lim

National University of Singapore

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Osmium carbonyl clusters, especially the cluster [Os₃(CO) ₁₀-(NCCH₃)₂], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number ofmorpho logical and apoptosis assays, all ofwhich pointed to the induction of apoptosis.

Original language	English
Pages (from-to)	1269-1275
Number of pages	7
Journal	ChemMedChem
Volume	3
Issue number	8
DOIs	https://doi.org/10.1002/cmdc.200800069
Publication status	Published - Aug 18 2008
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
General Pharmacology, Toxicology and Pharmaceutics
Organic Chemistry

Keywords

Antitumor agents
Apoptosis
Cancer
Cluster compounds
Osmium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cmdc.200800069

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abstract = "Osmium carbonyl clusters, especially the cluster [Os3(CO) 10-(NCCH3)2], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number ofmorpho logical and apoptosis assays, all ofwhich pointed to the induction of apoptosis.",

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T1 - Osmium carbonyl clusters

T2 - A new class of apoptosis inducing agents

AU - Kong, Kien Voon

AU - Leong, Weng Kee

AU - Ng, Swee Phyaw

AU - Nguyen, Thanh Hung

AU - Lim, Lina H.K.

PY - 2008/8/18

Y1 - 2008/8/18

N2 - Osmium carbonyl clusters, especially the cluster [Os3(CO) 10-(NCCH3)2], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number ofmorpho logical and apoptosis assays, all ofwhich pointed to the induction of apoptosis.

AB - Osmium carbonyl clusters, especially the cluster [Os3(CO) 10-(NCCH3)2], were found to be active against four cancer cell lines, namely, ER+ breast carcinoma (MCF-7), ER- breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620), and hepatocarcinoma (Hep G2). The mode of action was studied in MCF-7 and MDA-MB-231 cell lines by a number ofmorpho logical and apoptosis assays, all ofwhich pointed to the induction of apoptosis.

KW - Antitumor agents

KW - Apoptosis

KW - Cancer

KW - Cluster compounds

KW - Osmium

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JO - ChemMedChem

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ER -

Osmium carbonyl clusters: A new class of apoptosis inducing agents

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

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