TY - JOUR
T1 - Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries
T2 - a NIRS Study
AU - Cataldo, Ilaria
AU - Neoh, Michelle Jin Yee
AU - Chew, Wei Fang
AU - Foo, Jia Nee
AU - Lepri, Bruno
AU - Esposito, Gianluca
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The ability to interpret and regulate emotions relies on experiences of emotional socialization, obtained firstly through the interaction with the parents, and on genetic features that affect how individuals take on social situations. Evidence from the genetic field states that specific allelic variations of the oxytocin receptor gene polymorphisms regulate physiological modulation of human behavior, especially concerning responses to social cues and affiliative behaviors. Starting from this gene-by-environment interaction frame, we assessed 102 young adults for OXTr rs53576 and rs2254298, recalled parental bonding (using the Parental Bonding Instrument), and recorded participants’ neural responses to social stressors using Near InfraRed Spectroscopy (NIRS). The results highlight that higher genetic susceptibility (G/G homozygous) to familiar context and positive early life interactions modulate more optimal neural responses to general social cues, in terms of promptness to action. With regards to the dimensions of parental bonding, we found lateralized effects, with greater activation in the right prefrontal cortex for Care subscales, and on the left side of the prefrontal cortex for Overprotection. Results provide evidence to understand the neurological mechanisms behind the negative impact of poor parenting practices on the child.
AB - The ability to interpret and regulate emotions relies on experiences of emotional socialization, obtained firstly through the interaction with the parents, and on genetic features that affect how individuals take on social situations. Evidence from the genetic field states that specific allelic variations of the oxytocin receptor gene polymorphisms regulate physiological modulation of human behavior, especially concerning responses to social cues and affiliative behaviors. Starting from this gene-by-environment interaction frame, we assessed 102 young adults for OXTr rs53576 and rs2254298, recalled parental bonding (using the Parental Bonding Instrument), and recorded participants’ neural responses to social stressors using Near InfraRed Spectroscopy (NIRS). The results highlight that higher genetic susceptibility (G/G homozygous) to familiar context and positive early life interactions modulate more optimal neural responses to general social cues, in terms of promptness to action. With regards to the dimensions of parental bonding, we found lateralized effects, with greater activation in the right prefrontal cortex for Care subscales, and on the left side of the prefrontal cortex for Overprotection. Results provide evidence to understand the neurological mechanisms behind the negative impact of poor parenting practices on the child.
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U2 - 10.1038/s41598-020-65582-0
DO - 10.1038/s41598-020-65582-0
M3 - Article
C2 - 32444796
AN - SCOPUS:85085264861
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 8588
ER -