PAAR proteins act as the ‘sorting hat’ of the type VI vsecretion system

Thomas E. Wood; Sophie A. Howard; Sarah Wettstadt; Alain Filloux

doi:10.1099/mic.0.000842

PAAR proteins act as the ‘sorting hat’ of the type VI vsecretion system

Thomas E. Wood, Sophie A. Howard, Sarah Wettstadt, Alain Filloux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Bacteria exist in polymicrobial environments and compete to prevail in a niche. The type VI secretion system (T6SS) is a nanomachine employed by Gram-negative bacteria to deliver effector proteins into target cells. Consequently, T6SS-positive bacteriproduce a wealth of antibacterial effector proteins to promote their survival among a prokaryotic community. These toxins arloaded onto the VgrG–PAAR spike and Hcp tube of the T6SS apparatus and recent work has started to document the specificit.

Original language	English
Pages (from-to)	1208-1218
Number of pages	11
Journal	Microbiology
Volume	165
Issue number	11
DOIs	https://doi.org/10.1099/mic.0.000842
Publication status	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 The Authors.

ASJC Scopus Subject Areas

Microbiology

Keywords

Abbreviations: Hcp
Effector
Haemolysin-coregulated protein
Immunity
IPTG
Isopropyl-β-D
PAAR
Type VI secretion system
VgrG

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10.1099/mic.0.000842

Cite this

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title = "PAAR proteins act as the {\textquoteleft}sorting hat{\textquoteright} of the type VI vsecretion system",

abstract = "Bacteria exist in polymicrobial environments and compete to prevail in a niche. The type VI secretion system (T6SS) is a nanomachine employed by Gram-negative bacteria to deliver effector proteins into target cells. Consequently, T6SS-positive bacteriproduce a wealth of antibacterial effector proteins to promote their survival among a prokaryotic community. These toxins arloaded onto the VgrG–PAAR spike and Hcp tube of the T6SS apparatus and recent work has started to document the specificit.",

keywords = "Abbreviations: Hcp, Effector, Haemolysin-coregulated protein, Immunity, IPTG, Isopropyl-β-D, PAAR, Type VI secretion system, VgrG",

author = "Wood, {Thomas E.} and Howard, {Sophie A.} and Sarah Wettstadt and Alain Filloux",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors.",

year = "2019",

doi = "10.1099/mic.0.000842",

language = "English",

volume = "165",

pages = "1208--1218",

journal = "Microbiology",

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TY - JOUR

T1 - PAAR proteins act as the ‘sorting hat’ of the type VI vsecretion system

AU - Wood, Thomas E.

AU - Howard, Sophie A.

AU - Wettstadt, Sarah

AU - Filloux, Alain

PY - 2019

Y1 - 2019

N2 - Bacteria exist in polymicrobial environments and compete to prevail in a niche. The type VI secretion system (T6SS) is a nanomachine employed by Gram-negative bacteria to deliver effector proteins into target cells. Consequently, T6SS-positive bacteriproduce a wealth of antibacterial effector proteins to promote their survival among a prokaryotic community. These toxins arloaded onto the VgrG–PAAR spike and Hcp tube of the T6SS apparatus and recent work has started to document the specificit.

AB - Bacteria exist in polymicrobial environments and compete to prevail in a niche. The type VI secretion system (T6SS) is a nanomachine employed by Gram-negative bacteria to deliver effector proteins into target cells. Consequently, T6SS-positive bacteriproduce a wealth of antibacterial effector proteins to promote their survival among a prokaryotic community. These toxins arloaded onto the VgrG–PAAR spike and Hcp tube of the T6SS apparatus and recent work has started to document the specificit.

KW - Abbreviations: Hcp

KW - Effector

KW - Haemolysin-coregulated protein

KW - Immunity

KW - IPTG

KW - Isopropyl-β-D

KW - PAAR

KW - Type VI secretion system

KW - VgrG

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DO - 10.1099/mic.0.000842

M3 - Article

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AN - SCOPUS:85072279065

SN - 1350-0872

VL - 165

SP - 1208

EP - 1218

JO - Microbiology

JF - Microbiology

IS - 11

ER -

PAAR proteins act as the ‘sorting hat’ of the type VI vsecretion system

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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