Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding; Zhi Dao Huang; Zheng Li Liu; Tian Xiang Wang; Yun He Xu; Teck Peng Loh

doi:10.1039/c5cc10653b

Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Ran Ding, Zhi Dao Huang, Zheng Li Liu, Tian Xiang Wang, Yun He Xu^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

Original language	English
Pages (from-to)	5617-5620
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	32
DOIs	https://doi.org/10.1039/c5cc10653b
Publication status	Published - Apr 25 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2016.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c5cc10653b

Cite this

@article{7b936d13deb846ba8c9f1e9e298d51fe,

title = "Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls",

abstract = "Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.",

author = "Ran Ding and Huang, {Zhi Dao} and Liu, {Zheng Li} and Wang, {Tian Xiang} and Xu, {Yun He} and Loh, {Teck Peng}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

month = apr,

day = "25",

doi = "10.1039/c5cc10653b",

language = "English",

volume = "52",

pages = "5617--5620",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "32",

}

TY - JOUR

T1 - Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

AU - Ding, Ran

AU - Huang, Zhi Dao

AU - Liu, Zheng Li

AU - Wang, Tian Xiang

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2016/4/25

Y1 - 2016/4/25

N2 - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

AB - Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

UR - http://www.scopus.com/inward/record.url?scp=84964683928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964683928&partnerID=8YFLogxK

U2 - 10.1039/c5cc10653b

DO - 10.1039/c5cc10653b

M3 - Article

AN - SCOPUS:84964683928

SN - 1359-7345

VL - 52

SP - 5617

EP - 5620

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this