Palladium-catalyzed cross-coupling of indium homoenolate with aryl halide with wide functional group compatibility

Zhi Liang Shen; Yin Chang Lai; Colin Hong An Wong; Kelvin Kau Kiat Goh; Yong Sheng Yang; Hao Lun Cheong; Teck Peng Loh

doi:10.1021/ol102755q

Palladium-catalyzed cross-coupling of indium homoenolate with aryl halide with wide functional group compatibility

Zhi Liang Shen, Yin Chang Lai, Colin Hong An Wong, Kelvin Kau Kiat Goh, Yong Sheng Yang, Hao Lun Cheong, Teck Peng Loh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

An efficient palladium-catalyzed cross-coupling of indium homoenolate with aryl halide is described. The reactions proceeded efficiently in DMA at 100 °C to afford the desired products of β-aryl ketones in moderate to good yields. Various important functional groups including COR, COOR, CHO, CN, OH, and NO₂ can be well tolerated in the protocol.

Original language	English
Pages (from-to)	422-425
Number of pages	4
Journal	Organic Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1021/ol102755q
Publication status	Published - Feb 4 2011
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol102755q

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abstract = "An efficient palladium-catalyzed cross-coupling of indium homoenolate with aryl halide is described. The reactions proceeded efficiently in DMA at 100 °C to afford the desired products of β-aryl ketones in moderate to good yields. Various important functional groups including COR, COOR, CHO, CN, OH, and NO2 can be well tolerated in the protocol.",

author = "Shen, {Zhi Liang} and Lai, {Yin Chang} and Wong, {Colin Hong An} and Goh, {Kelvin Kau Kiat} and Yang, {Yong Sheng} and Cheong, {Hao Lun} and Loh, {Teck Peng}",

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AU - Shen, Zhi Liang

AU - Lai, Yin Chang

AU - Wong, Colin Hong An

AU - Goh, Kelvin Kau Kiat

AU - Yang, Yong Sheng

AU - Cheong, Hao Lun

AU - Loh, Teck Peng

PY - 2011/2/4

Y1 - 2011/2/4

N2 - An efficient palladium-catalyzed cross-coupling of indium homoenolate with aryl halide is described. The reactions proceeded efficiently in DMA at 100 °C to afford the desired products of β-aryl ketones in moderate to good yields. Various important functional groups including COR, COOR, CHO, CN, OH, and NO2 can be well tolerated in the protocol.

AB - An efficient palladium-catalyzed cross-coupling of indium homoenolate with aryl halide is described. The reactions proceeded efficiently in DMA at 100 °C to afford the desired products of β-aryl ketones in moderate to good yields. Various important functional groups including COR, COOR, CHO, CN, OH, and NO2 can be well tolerated in the protocol.

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Palladium-catalyzed cross-coupling of indium homoenolate with aryl halide with wide functional group compatibility

Abstract

ASJC Scopus Subject Areas

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