Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami; Sreekumar Pankajakshan; Gang Chen; Teck Peng Loh

doi:10.1021/acs.orglett.7b01859

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Manikantha Maraswami, Sreekumar Pankajakshan, Gang Chen^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.

Original language	English
Pages (from-to)	4223-4226
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.7b01859
Publication status	Published - Aug 18 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.7b01859

Cite this

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abstract = "A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.",

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Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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