Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

Bing Jiang; Fei Fan Meng; Qiu Ju Liang; Yun He Xu; Teck Peng Loh

doi:10.1021/acs.orglett.7b00072

Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

Bing Jiang, Fei Fan Meng, Qiu Ju Liang, Yun He Xu^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.

Original language	English
Pages (from-to)	914-917
Number of pages	4
Journal	Organic Letters
Volume	19
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.7b00072
Publication status	Published - Feb 17 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/acs.orglett.7b00072

Cite this

@article{7ce154194df74c5796cfe04918ff5b06,

title = "Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles",

abstract = "A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.",

author = "Bing Jiang and Meng, \{Fei Fan\} and Liang, \{Qiu Ju\} and Xu, \{Yun He\} and Loh, \{Teck Peng\}",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = feb,

day = "17",

doi = "10.1021/acs.orglett.7b00072",

language = "English",

volume = "19",

pages = "914--917",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Palladium-Catalyzed Direct Intramolecular C-N Bond Formation

T2 - Access to Multisubstituted Dihydropyrroles

AU - Jiang, Bing

AU - Meng, Fei Fan

AU - Liang, Qiu Ju

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2017/2/17

Y1 - 2017/2/17

N2 - A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.

AB - A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.

UR - http://www.scopus.com/inward/record.url?scp=85013179674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013179674&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.7b00072

DO - 10.1021/acs.orglett.7b00072

M3 - Article

C2 - 28181813

AN - SCOPUS:85013179674

SN - 1523-7060

VL - 19

SP - 914

EP - 917

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this