Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Qiu Ju Liang; Bing Jiang; Yun He Xu; Teck Peng Loh

doi:10.1021/acs.joc.8b00991

Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Qiu Ju Liang, Bing Jiang, Yun He Xu^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

Original language	English
Pages (from-to)	8265-8271
Number of pages	7
Journal	Journal of Organic Chemistry
Volume	83
Issue number	15
DOIs	https://doi.org/10.1021/acs.joc.8b00991
Publication status	Published - Aug 3 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 American Chemical Society.

ASJC Scopus Subject Areas

Organic Chemistry

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10.1021/acs.joc.8b00991

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abstract = "A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.",

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AU - Liang, Qiu Ju

AU - Jiang, Bing

AU - Xu, Yun He

AU - Loh, Teck Peng

PY - 2018/8/3

Y1 - 2018/8/3

N2 - A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

AB - A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.

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Palladium-Catalyzed Regioselective Olefination of O-Acetyl Cyanohydrins

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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