Pd-catalyzed decarboxylative cross-coupling of perfluorobenzoic acids with simple arenes

Hai Qing Luo; Wen Dong; Teck Peng Loh

doi:10.1016/j.tetlet.2013.03.086

Pd-catalyzed decarboxylative cross-coupling of perfluorobenzoic acids with simple arenes

Hai Qing Luo^*, Wen Dong, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C-H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for the synthesis of fluorobiphenyl scaffolds under simple and mild conditions.

Original language	English
Pages (from-to)	2833-2836
Number of pages	4
Journal	Tetrahedron Letters
Volume	54
Issue number	22
DOIs	https://doi.org/10.1016/j.tetlet.2013.03.086
Publication status	Published - May 29 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

Keywords

Crosscoupling
Decarboxylative
Fluorobiphenyl
Pd-catalyzed
Simple arenas

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10.1016/j.tetlet.2013.03.086

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abstract = "Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C-H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for the synthesis of fluorobiphenyl scaffolds under simple and mild conditions.",

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author = "Luo, {Hai Qing} and Wen Dong and Loh, {Teck Peng}",

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AU - Luo, Hai Qing

AU - Dong, Wen

AU - Loh, Teck Peng

PY - 2013/5/29

Y1 - 2013/5/29

N2 - Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C-H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for the synthesis of fluorobiphenyl scaffolds under simple and mild conditions.

AB - Using a Pd/Ag bimetallic system, arylations of simple arenes with perfluorobenzoic acids have been achieved by decarboxylative C-H bond functionalization, providing the desired cross-coupling products in moderate to good yields. These straightforward protocols provide new and efficient methods for the synthesis of fluorobiphenyl scaffolds under simple and mild conditions.

KW - Crosscoupling

KW - Decarboxylative

KW - Fluorobiphenyl

KW - Pd-catalyzed

KW - Simple arenas

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JF - Tetrahedron Letters

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ER -

Pd-catalyzed decarboxylative cross-coupling of perfluorobenzoic acids with simple arenes

Abstract

ASJC Scopus Subject Areas

Keywords

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