Abstract
Stool testing is a widely accepted, non-invasive, technique for colorectal cancer (CRC) screening. Guaiac-based faecal occult blood test (gFOBT) screening has been proven to decrease CRC-related mortality; however gFOBT is hampered by a low sensitivity. Faecal immunochemical tests (FITs) have several advantages over gFOBT. First of all, FIT has a better sensitivity and higher uptake. Furthermore, the quantitative variant of the FIT allows choices on cut-off level for test-positivity according to colonoscopy resources available, personal risk profile, and/or intended detection rate in the screened population. Stool-based DNA (sDNA) tests aiming at the detection of specific DNA alterations may improve detection of CRC and adenomas compared to gFOBT screening, but large-scale population based studies are lacking. This review focuses on factors influencing test performance of those three stool based screening tests.
| Original language | English |
|---|---|
| Pages (from-to) | 479-492 |
| Number of pages | 14 |
| Journal | Bailliere's Best Practice and Research in Clinical Gastroenterology |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2010 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Gastroenterology
Keywords
- Adenomas
- Colorectal cancer
- Faecal DNA test
- Faecal immunochemical test
- FIT
- FOBT
- Guaiac-based faecal occult blood test
- Performance
- Screening
