Photoinduced alkylation of diazines with N-(acyloxy)phthalimides in the presence of triethylamine

Itziar Guerrero; Eugene Yew Kun Tan; Yuliang Liu; Lee J. Edwards; Shunsuke Chiba

doi:10.1055/a-2182-7416

Photoinduced alkylation of diazines with N-(acyloxy)phthalimides in the presence of triethylamine

Itziar Guerrero, Eugene Yew Kun Tan, Yuliang Liu, Lee J. Edwards, Shunsuke Chiba^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated in the presence of triethylamine (Et3N) under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.

Original language	English
Journal	Synthesis
DOIs	https://doi.org/10.1055/a-2182-7416
Publication status	Accepted/In press - 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Georg Thieme Verlag. All rights reserved.

ASJC Scopus Subject Areas

Catalysis
Organic Chemistry

Keywords

diazines
electron-donoracceptor (EDA) complexes
Minisci-type alkylation
N-(acyloxy)phthalimides
radicals

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10.1055/a-2182-7416

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abstract = "A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated in the presence of triethylamine (Et3N) under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.",

keywords = "diazines, electron-donoracceptor (EDA) complexes, Minisci-type alkylation, N-(acyloxy)phthalimides, radicals",

author = "Itziar Guerrero and Tan, {Eugene Yew Kun} and Yuliang Liu and Edwards, {Lee J.} and Shunsuke Chiba",

year = "2023",

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language = "English",

journal = "Synthesis",

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T1 - Photoinduced alkylation of diazines with N-(acyloxy)phthalimides in the presence of triethylamine

AU - Guerrero, Itziar

AU - Tan, Eugene Yew Kun

AU - Liu, Yuliang

AU - Edwards, Lee J.

AU - Chiba, Shunsuke

PY - 2023

Y1 - 2023

N2 - A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated in the presence of triethylamine (Et3N) under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.

AB - A photochemical protocol for the alkylation of diazines (pyrimidines, pyrazines and pyridazines) with N-(acyloxy)phthalimides has been developed. The process is facilitated in the presence of triethylamine (Et3N) under irradiation with 427-390 nm light, enabling rapid cross-coupling reactions to construct a wide range of alkylated diazines.

KW - diazines

KW - electron-donoracceptor (EDA) complexes

KW - Minisci-type alkylation

KW - N-(acyloxy)phthalimides

KW - radicals

UR - http://www.scopus.com/inward/record.url?scp=85173018156&partnerID=8YFLogxK

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JO - Synthesis

JF - Synthesis

ER -

Photoinduced alkylation of diazines with N-(acyloxy)phthalimides in the presence of triethylamine

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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