Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Changyu Cao; Da Bao Zha; Chencheng Sun; Nan Yang; Shi Tao; Peng Jiang; Yan Ling Li; Zheye Zhang; Dong Sheng Li; Xuejiao Song; Peng Chen; Xiaochen Dong

doi:10.1016/j.jcis.2024.12.088

Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Changyu Cao, Da Bao Zha, Chencheng Sun^*, Nan Yang, Shi Tao, Peng Jiang, Yan Ling Li, Zheye Zhang, Dong Sheng Li, Xuejiao Song, Peng Chen, Xiaochen Dong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A multi-functional single-Fe-atom nanozyme (Fe-SAzyme) is designed, integrating the near-infrared photothermal property, the ability to carry chemoagent (doxorubicin – DOX), and nanocatalytic activities mimicking peroxidase, oxidase, and glutathione oxidase. The nanocatalytic activities act cooperatively to effectively produce cytotoxic radicals in the tumor microenvironment (TME), thereby leading to ferroptosis of cancer cells. The photothermal effect not only enhances the nanocatalytic therapy but also enables photothermal therapy. And release of DOX upon triggering by TME and the Fe-SAzyme activities enables chemotherapy to induce apoptosis of cancer cells. Such targeted and synergistic multi-modality treatment achieves complete tumor elimination without obvious side effects. Further, the underlying working mechanism is carefully revealed both theoretically and experimentally.

Original language	English
Pages (from-to)	398-407
Number of pages	10
Journal	Journal of Colloid and Interface Science
Volume	683
DOIs	https://doi.org/10.1016/j.jcis.2024.12.088
Publication status	Published - Apr 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

Keywords

Chemotherapy
Ferroptosis
Nanocatalytic therapy
Photothermal therapy
Single-atom nanozyme

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jcis.2024.12.088

Cite this

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title = "Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme",

abstract = "A multi-functional single-Fe-atom nanozyme (Fe-SAzyme) is designed, integrating the near-infrared photothermal property, the ability to carry chemoagent (doxorubicin – DOX), and nanocatalytic activities mimicking peroxidase, oxidase, and glutathione oxidase. The nanocatalytic activities act cooperatively to effectively produce cytotoxic radicals in the tumor microenvironment (TME), thereby leading to ferroptosis of cancer cells. The photothermal effect not only enhances the nanocatalytic therapy but also enables photothermal therapy. And release of DOX upon triggering by TME and the Fe-SAzyme activities enables chemotherapy to induce apoptosis of cancer cells. Such targeted and synergistic multi-modality treatment achieves complete tumor elimination without obvious side effects. Further, the underlying working mechanism is carefully revealed both theoretically and experimentally.",

keywords = "Chemotherapy, Ferroptosis, Nanocatalytic therapy, Photothermal therapy, Single-atom nanozyme",

author = "Changyu Cao and Zha, {Da Bao} and Chencheng Sun and Nan Yang and Shi Tao and Peng Jiang and Li, {Yan Ling} and Zheye Zhang and Li, {Dong Sheng} and Xuejiao Song and Peng Chen and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2025",

month = apr,

doi = "10.1016/j.jcis.2024.12.088",

language = "English",

volume = "683",

pages = "398--407",

journal = "Journal of Colloid and Interface Science",

issn = "0021-9797",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

AU - Cao, Changyu

AU - Zha, Da Bao

AU - Sun, Chencheng

AU - Yang, Nan

AU - Tao, Shi

AU - Jiang, Peng

AU - Li, Yan Ling

AU - Zhang, Zheye

AU - Li, Dong Sheng

AU - Song, Xuejiao

AU - Chen, Peng

AU - Dong, Xiaochen

PY - 2025/4

Y1 - 2025/4

N2 - A multi-functional single-Fe-atom nanozyme (Fe-SAzyme) is designed, integrating the near-infrared photothermal property, the ability to carry chemoagent (doxorubicin – DOX), and nanocatalytic activities mimicking peroxidase, oxidase, and glutathione oxidase. The nanocatalytic activities act cooperatively to effectively produce cytotoxic radicals in the tumor microenvironment (TME), thereby leading to ferroptosis of cancer cells. The photothermal effect not only enhances the nanocatalytic therapy but also enables photothermal therapy. And release of DOX upon triggering by TME and the Fe-SAzyme activities enables chemotherapy to induce apoptosis of cancer cells. Such targeted and synergistic multi-modality treatment achieves complete tumor elimination without obvious side effects. Further, the underlying working mechanism is carefully revealed both theoretically and experimentally.

AB - A multi-functional single-Fe-atom nanozyme (Fe-SAzyme) is designed, integrating the near-infrared photothermal property, the ability to carry chemoagent (doxorubicin – DOX), and nanocatalytic activities mimicking peroxidase, oxidase, and glutathione oxidase. The nanocatalytic activities act cooperatively to effectively produce cytotoxic radicals in the tumor microenvironment (TME), thereby leading to ferroptosis of cancer cells. The photothermal effect not only enhances the nanocatalytic therapy but also enables photothermal therapy. And release of DOX upon triggering by TME and the Fe-SAzyme activities enables chemotherapy to induce apoptosis of cancer cells. Such targeted and synergistic multi-modality treatment achieves complete tumor elimination without obvious side effects. Further, the underlying working mechanism is carefully revealed both theoretically and experimentally.

KW - Chemotherapy

KW - Ferroptosis

KW - Nanocatalytic therapy

KW - Photothermal therapy

KW - Single-atom nanozyme

UR - http://www.scopus.com/inward/record.url?scp=85212114828&partnerID=8YFLogxK

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U2 - 10.1016/j.jcis.2024.12.088

DO - 10.1016/j.jcis.2024.12.088

M3 - Article

AN - SCOPUS:85212114828

SN - 0021-9797

VL - 683

SP - 398

EP - 407

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

ER -

Photothermally-enhanced ferroptotic-chemo therapy enabled by ZIF-derived multizyme

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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