TY - GEN
T1 - Pollen Shape Particles for Pulmonary Drug Delivery
T2 - 13th International Conference on Biomedical Engineering, ICBME 2008
AU - Hassan, Meer Saiful
AU - Lau, Raymond
PY - 2009
Y1 - 2009
N2 - Pollen shape hydroxyapatite (HA) particles have been synthesized in this study. The flow and deposition properties of these pollen shape particles are compared with needle, cube and plate shape particles of similar size range of around 5 μm. The flow properties of the particles are characterized by the angle of slide (θ) method. The deposition properties of the particles are studied in vitro by using an eight-staged Anderson cascade impactor with a Rotahaler®. Pollen shape particles exhibits better flow behavior, higher emitted dose and higher fine particle fraction compare to particles of other shapes. The surface structure of the pollen shape particles increases the distance between particles, hence reduce the interparticle forces and aggregation tendency.
AB - Pollen shape hydroxyapatite (HA) particles have been synthesized in this study. The flow and deposition properties of these pollen shape particles are compared with needle, cube and plate shape particles of similar size range of around 5 μm. The flow properties of the particles are characterized by the angle of slide (θ) method. The deposition properties of the particles are studied in vitro by using an eight-staged Anderson cascade impactor with a Rotahaler®. Pollen shape particles exhibits better flow behavior, higher emitted dose and higher fine particle fraction compare to particles of other shapes. The surface structure of the pollen shape particles increases the distance between particles, hence reduce the interparticle forces and aggregation tendency.
KW - cascade impactor
KW - emitted dose
KW - fine particle fraction
KW - pollen shape particles
KW - Pulmonary drug delivery
UR - http://www.scopus.com/inward/record.url?scp=84891922595&partnerID=8YFLogxK
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U2 - 10.1007/978-3-540-92841-6_354
DO - 10.1007/978-3-540-92841-6_354
M3 - Conference contribution
AN - SCOPUS:84891922595
SN - 9783540928409
T3 - IFMBE Proceedings
SP - 1434
EP - 1437
BT - 13th International Conference on Biomedical Engineering - ICBME 2008
Y2 - 3 December 2008 through 6 December 2008
ER -