Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging

G. Suresh; R. V. Ramanujan; T. W. Chong; R. S. Chaughule; S. Pednekar; D. P. Patkar

doi:10.1166/nnl.2015.1944

Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging

G. Suresh, R. V. Ramanujan^*, T. W. Chong, R. S. Chaughule, S. Pednekar, D. P. Patkar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe₃O₄ core to prepare Fe₃O₄-PNIPAM core-shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core-shell nanostructured samples with different hydrodynamic sizes were prepared. Zeta potential measurements showed that these samples are highly stable in aqueous environment. These core-shell structures were shown to be better contrast agents than conventional Gd chelates for magnetic resonance imaging (MRI). Thus this core-shell Fe₃O₄-PNIPAM system can be used for multimodal theranostics as a drug carrier, hyperthermia agent and for MRI.

Original language	English
Pages (from-to)	15-19
Number of pages	5
Journal	Nanoscience and Nanotechnology Letters
Volume	7
Issue number	1
DOIs	https://doi.org/10.1166/nnl.2015.1944
Publication status	Published - Jan 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2015 American Scientific Publishers All rights reserved.

ASJC Scopus Subject Areas

General Materials Science

Keywords

Contrast agent
Core-shell
Magnetite
MRI
Nanoparticles
Thermo-responsive

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10.1166/nnl.2015.1944

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abstract = "Thermosensitive poly(N-isopropyl acrylamide) (PNIPAM) has been coated on Fe3O4 core to prepare Fe3O4-PNIPAM core-shell nanostructures. The PNIPAM coating has the ability to swell and shrink due to changes in temperature. Core-shell nanostructured samples with different hydrodynamic sizes were prepared. Zeta potential measurements showed that these samples are highly stable in aqueous environment. These core-shell structures were shown to be better contrast agents than conventional Gd chelates for magnetic resonance imaging (MRI). Thus this core-shell Fe3O4-PNIPAM system can be used for multimodal theranostics as a drug carrier, hyperthermia agent and for MRI.",

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AU - Ramanujan, R. V.

AU - Chong, T. W.

AU - Chaughule, R. S.

AU - Pednekar, S.

AU - Patkar, D. P.

PY - 2015/1/1

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Poly(N-isopropyl acrylamide) coated magnetite nanoparticles as contrast agents for magnetic resonance imaging

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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