TY - JOUR
T1 - Posterior scleral birefringence measured by triple-input polarization-sensitive imaging as a biomarker of myopia progression
AU - Liu, Xinyu
AU - Jiang, Liqin
AU - Ke, Mengyuan
AU - Sigal, Ian A.
AU - Chua, Jacqueline
AU - Hoang, Quan V.
AU - Chia, Audrey Wi
AU - Najjar, Raymond P.
AU - Tan, Bingyao
AU - Cheong, Jocelyn
AU - Bellemo, Valentina
AU - Chong, Rachel S.
AU - Girard, Michaël J.A.
AU - Ang, Marcus
AU - Liu, Mengyang
AU - Garhöfer, Gerhard
AU - Barathi, Veluchamy A.
AU - Saw, Seang Mei
AU - Villiger, Martin
AU - Schmetterer, Leopold
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/8
Y1 - 2023/8
N2 - In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input polarization-sensitive OCT may help establish posterior scleral birefringence as a non-invasive biomarker for assessing the progression of myopia.
AB - In myopic eyes, pathological remodelling of collagen in the posterior sclera has mostly been observed ex vivo. Here we report the development of triple-input polarization-sensitive optical coherence tomography (OCT) for measuring posterior scleral birefringence. In guinea pigs and humans, the technique offers superior imaging sensitivities and accuracies than dual-input polarization-sensitive OCT. In 8-week-long studies with young guinea pigs, scleral birefringence was positively correlated with spherical equivalent refractive errors and predicted the onset of myopia. In a cross-sectional study involving adult individuals, scleral birefringence was associated with myopia status and negatively correlated with refractive errors. Triple-input polarization-sensitive OCT may help establish posterior scleral birefringence as a non-invasive biomarker for assessing the progression of myopia.
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U2 - 10.1038/s41551-023-01062-w
DO - 10.1038/s41551-023-01062-w
M3 - Article
C2 - 37365268
AN - SCOPUS:85162909176
SN - 2157-846X
VL - 7
SP - 986
EP - 1000
JO - Nature Biomedical Engineering
JF - Nature Biomedical Engineering
IS - 8
ER -