Precancerous lesions in the stomach: From biology to clinical patient management

Massimo Rugge; Lisette G. Capelle; Rocco Cappellesso; Donato Nitti; Ernst J. Kuipers

doi:10.1016/j.bpg.2012.12.007

Precancerous lesions in the stomach: From biology to clinical patient management

Massimo Rugge^*, Lisette G. Capelle, Rocco Cappellesso, Donato Nitti, Ernst J. Kuipers

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

94 Citations (Scopus)

Abstract

Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.

Original language	English
Pages (from-to)	205-223
Number of pages	19
Journal	Bailliere's Best Practice and Research in Clinical Gastroenterology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.bpg.2012.12.007
Publication status	Published - Apr 2013
Externally published	Yes

ASJC Scopus Subject Areas

Gastroenterology

Keywords

Gastric cancer
Gastritis
Gastritis staging
Precancerous gastric lesions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bpg.2012.12.007

Cite this

@article{0e610c5fe81c47edbed653e72cd3bb26,

title = "Precancerous lesions in the stomach: From biology to clinical patient management",

abstract = "Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.",

keywords = "Gastric cancer, Gastritis, Gastritis staging, Precancerous gastric lesions",

author = "Massimo Rugge and Capelle, {Lisette G.} and Rocco Cappellesso and Donato Nitti and Kuipers, {Ernst J.}",

year = "2013",

month = apr,

doi = "10.1016/j.bpg.2012.12.007",

language = "English",

volume = "27",

pages = "205--223",

journal = "Bailliere's Best Practice and Research in Clinical Gastroenterology",

issn = "1521-6918",

publisher = "Bailliere Tindall Ltd",

number = "2",

}

TY - JOUR

T1 - Precancerous lesions in the stomach

T2 - From biology to clinical patient management

AU - Rugge, Massimo

AU - Capelle, Lisette G.

AU - Cappellesso, Rocco

AU - Nitti, Donato

AU - Kuipers, Ernst J.

PY - 2013/4

Y1 - 2013/4

N2 - Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.

AB - Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.

KW - Gastric cancer

KW - Gastritis

KW - Gastritis staging

KW - Precancerous gastric lesions

UR - http://www.scopus.com/inward/record.url?scp=84879788200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879788200&partnerID=8YFLogxK

U2 - 10.1016/j.bpg.2012.12.007

DO - 10.1016/j.bpg.2012.12.007

M3 - Review article

AN - SCOPUS:84879788200

SN - 1521-6918

VL - 27

SP - 205

EP - 223

JO - Bailliere's Best Practice and Research in Clinical Gastroenterology

JF - Bailliere's Best Practice and Research in Clinical Gastroenterology

IS - 2

ER -

Precancerous lesions in the stomach: From biology to clinical patient management

Abstract

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this