Preliminary results: Exploring the interactions of quantum dots whole blood components

Hans C. Fischer; Eliseo Papa; Lichuan Liu; K. Sandy Pang; Warren C.W. Chan

doi:10.1117/12.629344

Preliminary results: Exploring the interactions of quantum dots whole blood components

Hans C. Fischer^*, Eliseo Papa, Lichuan Liu, K. Sandy Pang, Warren C.W. Chan

^*Corresponding author for this work

University of Toronto

Research output: Contribution to journal › Conference article › peer-review

1 Citation (Scopus)

Abstract

Biocompatible ZnS capped CdSe fluorescent semiconductor nanocrystals (quantum dots, QDs) exhibit great potential as imaging agents with biomedical and clinical relevance. However, little is known about the fate of the quantum dots in vivo, and the importance of chemical and physical composition that may influence their behavior in vivo. When the QDs are introduced in vivo, the first interactions with blood components will dictate their kinetic behavior in vivo. We present some preliminary results that demonstrate the interactions of the quantum dots with plasma proteins and that quantum dots can be trapped in fibrous networks.

Original language	English
Article number	59690E
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5969
DOIs	https://doi.org/10.1117/12.629344
Publication status	Published - 2005
Externally published	Yes
Event	Photonic Applications in Biosensing and Imaging - Toronto, ON, Canada Duration: Sept 12 2005 → Sept 14 2005

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Keywords

Biodistribution
ICP-AES
Pharmacokinetics
Quantum dots
Reticuloendothelial system

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10.1117/12.629344

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title = "Preliminary results: Exploring the interactions of quantum dots whole blood components",

abstract = "Biocompatible ZnS capped CdSe fluorescent semiconductor nanocrystals (quantum dots, QDs) exhibit great potential as imaging agents with biomedical and clinical relevance. However, little is known about the fate of the quantum dots in vivo, and the importance of chemical and physical composition that may influence their behavior in vivo. When the QDs are introduced in vivo, the first interactions with blood components will dictate their kinetic behavior in vivo. We present some preliminary results that demonstrate the interactions of the quantum dots with plasma proteins and that quantum dots can be trapped in fibrous networks.",

keywords = "Biodistribution, ICP-AES, Pharmacokinetics, Quantum dots, Reticuloendothelial system",

author = "Fischer, {Hans C.} and Eliseo Papa and Lichuan Liu and Pang, {K. Sandy} and Chan, {Warren C.W.}",

year = "2005",

doi = "10.1117/12.629344",

language = "English",

volume = "5969",

journal = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

issn = "1605-7422",

publisher = "SPIE",

note = "Photonic Applications in Biosensing and Imaging ; Conference date: 12-09-2005 Through 14-09-2005",

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TY - JOUR

T1 - Preliminary results

T2 - Photonic Applications in Biosensing and Imaging

AU - Fischer, Hans C.

AU - Papa, Eliseo

AU - Liu, Lichuan

AU - Pang, K. Sandy

AU - Chan, Warren C.W.

PY - 2005

Y1 - 2005

N2 - Biocompatible ZnS capped CdSe fluorescent semiconductor nanocrystals (quantum dots, QDs) exhibit great potential as imaging agents with biomedical and clinical relevance. However, little is known about the fate of the quantum dots in vivo, and the importance of chemical and physical composition that may influence their behavior in vivo. When the QDs are introduced in vivo, the first interactions with blood components will dictate their kinetic behavior in vivo. We present some preliminary results that demonstrate the interactions of the quantum dots with plasma proteins and that quantum dots can be trapped in fibrous networks.

AB - Biocompatible ZnS capped CdSe fluorescent semiconductor nanocrystals (quantum dots, QDs) exhibit great potential as imaging agents with biomedical and clinical relevance. However, little is known about the fate of the quantum dots in vivo, and the importance of chemical and physical composition that may influence their behavior in vivo. When the QDs are introduced in vivo, the first interactions with blood components will dictate their kinetic behavior in vivo. We present some preliminary results that demonstrate the interactions of the quantum dots with plasma proteins and that quantum dots can be trapped in fibrous networks.

KW - Biodistribution

KW - ICP-AES

KW - Pharmacokinetics

KW - Quantum dots

KW - Reticuloendothelial system

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U2 - 10.1117/12.629344

DO - 10.1117/12.629344

M3 - Conference article

AN - SCOPUS:33244482790

SN - 1605-7422

VL - 5969

JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

M1 - 59690E

Y2 - 12 September 2005 through 14 September 2005

ER -

Preliminary results: Exploring the interactions of quantum dots whole blood components

Abstract

ASJC Scopus Subject Areas

Keywords

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