Abstract
Since 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), the component to keep structure of mRNA-lipid nanoparticle (LNP), is known to cause adverse effects, the replacement of DSPC with the combination of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and 1-stearoyl-2-hydroxy-sn-glycero-3-phospho ethanolamine (SHPE) was investigated. Specifically, when DSPC of mRNA-LNP was replaced by an 11:1 ratio of DSPE:SHPE, it was found that the size and permeability of mRNA-LNP were the same as those of mRNA-LNP containing DSPC in terms of stability. This result appears to be due to lipid geometry - the ratio of lipid volume to head group area and lipid length.
| Original language | English |
|---|---|
| Journal | Tenside, Surfactants, Detergents |
| DOIs | |
| Publication status | Accepted/In press - 2024 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2024 the author(s), published by De Gruyter, Berlin/Boston.
ASJC Scopus Subject Areas
- General Chemistry
- General Chemical Engineering
- Condensed Matter Physics
Keywords
- DSPC replacement
- lipid nanoparticle
- permeability
- size
- stability