Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis

Huihua Sun, Rong Kong, Di Zhu, Min Lu, Qiang Ji, Chong Wai Liew, Julien Lescar, Guofu Zhong*, Zhao Xun Liang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.

Original languageEnglish
Pages (from-to)7399-7401
Number of pages3
JournalChemical Communications
Issue number47
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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