Properties and hydrolysis of PLGA and PLLA cross-linked with electron beam radiation

Lester Phong; Ernest Sheng Chou Han; Sijing Xiong; Jie Pan; Say Chye Joachim Loo

doi:10.1016/j.polymdegradstab.2010.02.012

Properties and hydrolysis of PLGA and PLLA cross-linked with electron beam radiation

Lester Phong, Ernest Sheng Chou Han, Sijing Xiong, Jie Pan, Say Chye Joachim Loo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Radiation has been used as a processing tool to modify the properties of polymers. The aim of this study is to understand how electron beam radiation, together with pentaerythritol tetraacrylate (PTTA) as a tetra-functional monomer, can alter the properties (i.e. thermal and mechanical) and hydrolysis rates of PLGA and PLLA. The effects of radiation dose and PFM concentration on the physical properties of the polymers were investigated. The results showed that upon irradiation PLGA and PLLA cross-linked, and an increased in gel content was observed. Glass transition temperature (T_g) and mechanical properties of the polymers also increased. Cross-linked PLGA and PLLA samples were found to retard hydrolytic degradation. The mechanical properties of these polymers were also unaffected by hydrolysis. In summary, PLGA and PLLA cross-linked with PTTA were found to have enhanced mechanical properties and were able to retard hydrolytic degradation.

Original language	English
Pages (from-to)	771-777
Number of pages	7
Journal	Polymer Degradation and Stability
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.polymdegradstab.2010.02.012
Publication status	Published - May 2010
Externally published	Yes

ASJC Scopus Subject Areas

Condensed Matter Physics
Mechanics of Materials
Polymers and Plastics
Materials Chemistry

Keywords

Cross-linking
Electron beam radiation
Hydrolytic degradation
Mechanical properties
Pentaerythritol tetraacrylate
Poly-functional momomer

Access to Document

10.1016/j.polymdegradstab.2010.02.012

Cite this

@article{654fbb56fbe64505ad79e77c9e50fc14,

title = "Properties and hydrolysis of PLGA and PLLA cross-linked with electron beam radiation",

abstract = "Radiation has been used as a processing tool to modify the properties of polymers. The aim of this study is to understand how electron beam radiation, together with pentaerythritol tetraacrylate (PTTA) as a tetra-functional monomer, can alter the properties (i.e. thermal and mechanical) and hydrolysis rates of PLGA and PLLA. The effects of radiation dose and PFM concentration on the physical properties of the polymers were investigated. The results showed that upon irradiation PLGA and PLLA cross-linked, and an increased in gel content was observed. Glass transition temperature (Tg) and mechanical properties of the polymers also increased. Cross-linked PLGA and PLLA samples were found to retard hydrolytic degradation. The mechanical properties of these polymers were also unaffected by hydrolysis. In summary, PLGA and PLLA cross-linked with PTTA were found to have enhanced mechanical properties and were able to retard hydrolytic degradation.",

keywords = "Cross-linking, Electron beam radiation, Hydrolytic degradation, Mechanical properties, Pentaerythritol tetraacrylate, Poly-functional momomer",

author = "Lester Phong and Han, \{Ernest Sheng Chou\} and Sijing Xiong and Jie Pan and Loo, \{Say Chye Joachim\}",

year = "2010",

month = may,

doi = "10.1016/j.polymdegradstab.2010.02.012",

language = "English",

volume = "95",

pages = "771--777",

journal = "Polymer Degradation and Stability",

issn = "0141-3910",

publisher = "Elsevier Limited",

number = "5",

}

TY - JOUR

T1 - Properties and hydrolysis of PLGA and PLLA cross-linked with electron beam radiation

AU - Phong, Lester

AU - Han, Ernest Sheng Chou

AU - Xiong, Sijing

AU - Pan, Jie

AU - Loo, Say Chye Joachim

PY - 2010/5

Y1 - 2010/5

N2 - Radiation has been used as a processing tool to modify the properties of polymers. The aim of this study is to understand how electron beam radiation, together with pentaerythritol tetraacrylate (PTTA) as a tetra-functional monomer, can alter the properties (i.e. thermal and mechanical) and hydrolysis rates of PLGA and PLLA. The effects of radiation dose and PFM concentration on the physical properties of the polymers were investigated. The results showed that upon irradiation PLGA and PLLA cross-linked, and an increased in gel content was observed. Glass transition temperature (Tg) and mechanical properties of the polymers also increased. Cross-linked PLGA and PLLA samples were found to retard hydrolytic degradation. The mechanical properties of these polymers were also unaffected by hydrolysis. In summary, PLGA and PLLA cross-linked with PTTA were found to have enhanced mechanical properties and were able to retard hydrolytic degradation.

AB - Radiation has been used as a processing tool to modify the properties of polymers. The aim of this study is to understand how electron beam radiation, together with pentaerythritol tetraacrylate (PTTA) as a tetra-functional monomer, can alter the properties (i.e. thermal and mechanical) and hydrolysis rates of PLGA and PLLA. The effects of radiation dose and PFM concentration on the physical properties of the polymers were investigated. The results showed that upon irradiation PLGA and PLLA cross-linked, and an increased in gel content was observed. Glass transition temperature (Tg) and mechanical properties of the polymers also increased. Cross-linked PLGA and PLLA samples were found to retard hydrolytic degradation. The mechanical properties of these polymers were also unaffected by hydrolysis. In summary, PLGA and PLLA cross-linked with PTTA were found to have enhanced mechanical properties and were able to retard hydrolytic degradation.

KW - Cross-linking

KW - Electron beam radiation

KW - Hydrolytic degradation

KW - Mechanical properties

KW - Pentaerythritol tetraacrylate

KW - Poly-functional momomer

UR - http://www.scopus.com/inward/record.url?scp=77950300169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950300169&partnerID=8YFLogxK

U2 - 10.1016/j.polymdegradstab.2010.02.012

DO - 10.1016/j.polymdegradstab.2010.02.012

M3 - Article

AN - SCOPUS:77950300169

SN - 0141-3910

VL - 95

SP - 771

EP - 777

JO - Polymer Degradation and Stability

JF - Polymer Degradation and Stability

IS - 5

ER -

Properties and hydrolysis of PLGA and PLLA cross-linked with electron beam radiation

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this