Protein cages as theranostic agent carriers

Sierin Lim*, Tao Peng, Barindra Sana

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Protein cages can be engineered to tailor its function as carriers for therapeutic and diagnostic agents. They are formed by self-assembly of multiple subunits forming hollow spherical cage structures of nanometer size. Due to their proteinaceous nature, the protein cages allow facile modifications on its internal and external surfaces, as well as the subunit interfaces. Modifications on the internal surface allow conjugation of small molecule drugs or contrast agent while modifications on the external surface allow conjugation of various ligands including targeting ligands. The subunit interaction is of special interest in engineering controlled release property onto the protein cage. Two different protein cages, E2 protein and ferritin, are described.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Pages321-324
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventWorld Congress on Medical Physics and Biomedical Engineering - Beijing, China
Duration: May 26 2012May 31 2012

Publication series

NameIFMBE Proceedings
Volume39 IFMBE
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering
Country/TerritoryChina
CityBeijing
Period5/26/125/31/12

ASJC Scopus Subject Areas

  • Bioengineering
  • Biomedical Engineering

Keywords

  • controlled release
  • Drug delivery
  • MRI contrast agent
  • nanocages
  • nanocapsules

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