Abstract
Quantitative Phase Imaging (QPI) is a label-free imaging technique widely applied for investigating cellular properties (e.g., physical thickness and refractive index) [1]. Because it is based on the interference of light, the coherence of light source is a prerequisite. However, coherent illumination unavoidably encounters speckle noises, so several techniques have introduced low spatially or/and low temporally coherent light sources [2-4]. Nevertheless, those techniques have suffered from difficulties in system complexity and limited performances. Here, we proposed a speckle-less QPI using coherence-controlled frequency-comb (FC) as a light source. Since a frequency comb enables a lower phase noise in wide time scales, frequency-comb-referenced (FCR) QPI can help measuring dynamic motions at cellular level in live biological samples.
| Original language | English |
|---|---|
| Title of host publication | The European Conference on Lasers and Electro-Optics, CLEO_Europe_2019 |
| Publisher | Optica Publishing Group (formerly OSA) |
| ISBN (Print) | 9781728104690 |
| Publication status | Published - 2019 |
| Externally published | Yes |
| Event | The European Conference on Lasers and Electro-Optics, CLEO_Europe_2019 - Munich, Germany Duration: Jun 23 2019 → Jun 27 2019 |
Publication series
| Name | Optics InfoBase Conference Papers |
|---|---|
| Volume | Part F140-CLEO_Europe 2019 |
| ISSN (Electronic) | 2162-2701 |
Conference
| Conference | The European Conference on Lasers and Electro-Optics, CLEO_Europe_2019 |
|---|---|
| Country/Territory | Germany |
| City | Munich |
| Period | 6/23/19 → 6/27/19 |
Bibliographical note
Publisher Copyright:© 2019 IEEE
ASJC Scopus Subject Areas
- Electronic, Optical and Magnetic Materials
- Mechanics of Materials