Rapid access to bicyclic δ-lactones via carbene-catalyzed activation and cascade reaction of unsaturated carboxylic esters

Zhenqian Fu; Xingxing Wu; Yonggui Robin Chi

doi:10.1039/c5qo00348b

Rapid access to bicyclic δ-lactones via carbene-catalyzed activation and cascade reaction of unsaturated carboxylic esters

Zhenqian Fu, Xingxing Wu, Yonggui Robin Chi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obtained with high stereo-selectivities, and can readily undergo further transformations.

Original language	English
Pages (from-to)	145-149
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/c5qo00348b
Publication status	Published - Feb 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 the Partner Organisations.

ASJC Scopus Subject Areas

Organic Chemistry

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10.1039/c5qo00348b

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abstract = "Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obtained with high stereo-selectivities, and can readily undergo further transformations.",

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AU - Wu, Xingxing

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Y1 - 2016/2

N2 - Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obtained with high stereo-selectivities, and can readily undergo further transformations.

AB - Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obtained with high stereo-selectivities, and can readily undergo further transformations.

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Rapid access to bicyclic δ-lactones via carbene-catalyzed activation and cascade reaction of unsaturated carboxylic esters

Abstract

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