Real-time measurement of in-vitro and in-vivo blood flow with Fourier domain optical coherence tomography

Rainer Leitgeb*, Leopold Schmetterer, Wolfgang Drexler, Fatmire Berisha, Christoph Hitzenberger, Maciej Wojtkowski, Tomasz Bajraszewski, Adolf F. Fercher

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)

Abstract

We realized an in vivo Fourier domain optical coherence tomography (FD OCT) setup that allows acquiring retinal depth scans at a rate of 25.000 per second. We demonstrate the possibility to measure Doppler flow depth profile in specific regions of interest. The method to extract the flow profiles is based on a local phase analysis of the backscattered signal and allows for bidirectional Doppler flow imaging. The velocity resolution in tissue is 200μm/s. We verified the method by measuring pump controlled in vitro flow through a glass capillary. The system allows for a real- time colour encoded Doppler tomogram rate of 2-4 per second. We recorded the pulsatility of different vessels close to optic nerve head.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5316
DOIs
Publication statusPublished - 2004
Externally publishedYes
EventProgress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII - San Jose, CA, United States
Duration: Jan 26 2004Jan 28 2004

ASJC Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • Fourier domain
  • Laser Doppler Velocimetry
  • Optical Coherence Tomography
  • Partial Coherence Interferometry
  • Spectral domain

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