Recent Progress in Asymmetric Michael Additions Catalyzed by Chiral Phosphoric Acids

Zhongwen He; Teck Peng Loh; Lingli Bu; Yanyan He; Luyao Li

doi:10.1002/slct.202501096

Recent Progress in Asymmetric Michael Additions Catalyzed by Chiral Phosphoric Acids

Zhongwen He, Teck Peng Loh^*, Lingli Bu, Yanyan He, Luyao Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Chiral phosphoric acids (CPAs) exhibit bifunctional catalytic properties due to their unique structural features and chemical characteristics, leading to their widespread application in various common reactions. In addition, the Michael addition reaction holds significant importance in the field of organic chemistry, particularly among numerous reactions involving carbon–carbon and carbon–heteroatom bond forming. This minireview systematically introduced the structure and catalytic mechanism of chiral phosphoric acid and gave an overview on the development status of Michael addition catalyzed by chiral phosphoric acids, including actual Michael addition and hetero-Michael addition (aza-Michael addition, oxo-Michael addition, phospha-Michael addition, sulfa-Michael addition).

Original language	English
Article number	e01096
Journal	ChemistrySelect
Volume	10
Issue number	21
DOIs	https://doi.org/10.1002/slct.202501096
Publication status	Published - Jun 4 2025
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2025 Wiley-VCH GmbH.

ASJC Scopus Subject Areas

General Chemistry

Keywords

Asymmetric catalysis
Chiral phosphoric acids
Michael additions

Access to Document

10.1002/slct.202501096

Cite this

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title = "Recent Progress in Asymmetric Michael Additions Catalyzed by Chiral Phosphoric Acids",

abstract = "Chiral phosphoric acids (CPAs) exhibit bifunctional catalytic properties due to their unique structural features and chemical characteristics, leading to their widespread application in various common reactions. In addition, the Michael addition reaction holds significant importance in the field of organic chemistry, particularly among numerous reactions involving carbon–carbon and carbon–heteroatom bond forming. This minireview systematically introduced the structure and catalytic mechanism of chiral phosphoric acid and gave an overview on the development status of Michael addition catalyzed by chiral phosphoric acids, including actual Michael addition and hetero-Michael addition (aza-Michael addition, oxo-Michael addition, phospha-Michael addition, sulfa-Michael addition).",

keywords = "Asymmetric catalysis, Chiral phosphoric acids, Michael additions",

author = "Zhongwen He and Loh, {Teck Peng} and Lingli Bu and Yanyan He and Luyao Li",

note = "Publisher Copyright: {\textcopyright} 2025 Wiley-VCH GmbH.",

year = "2025",

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doi = "10.1002/slct.202501096",

language = "English",

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T1 - Recent Progress in Asymmetric Michael Additions Catalyzed by Chiral Phosphoric Acids

AU - He, Zhongwen

AU - Loh, Teck Peng

AU - Bu, Lingli

AU - He, Yanyan

AU - Li, Luyao

PY - 2025/6/4

Y1 - 2025/6/4

N2 - Chiral phosphoric acids (CPAs) exhibit bifunctional catalytic properties due to their unique structural features and chemical characteristics, leading to their widespread application in various common reactions. In addition, the Michael addition reaction holds significant importance in the field of organic chemistry, particularly among numerous reactions involving carbon–carbon and carbon–heteroatom bond forming. This minireview systematically introduced the structure and catalytic mechanism of chiral phosphoric acid and gave an overview on the development status of Michael addition catalyzed by chiral phosphoric acids, including actual Michael addition and hetero-Michael addition (aza-Michael addition, oxo-Michael addition, phospha-Michael addition, sulfa-Michael addition).

AB - Chiral phosphoric acids (CPAs) exhibit bifunctional catalytic properties due to their unique structural features and chemical characteristics, leading to their widespread application in various common reactions. In addition, the Michael addition reaction holds significant importance in the field of organic chemistry, particularly among numerous reactions involving carbon–carbon and carbon–heteroatom bond forming. This minireview systematically introduced the structure and catalytic mechanism of chiral phosphoric acid and gave an overview on the development status of Michael addition catalyzed by chiral phosphoric acids, including actual Michael addition and hetero-Michael addition (aza-Michael addition, oxo-Michael addition, phospha-Michael addition, sulfa-Michael addition).

KW - Asymmetric catalysis

KW - Chiral phosphoric acids

KW - Michael additions

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U2 - 10.1002/slct.202501096

DO - 10.1002/slct.202501096

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M1 - e01096

ER -

Recent Progress in Asymmetric Michael Additions Catalyzed by Chiral Phosphoric Acids

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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