Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Tong Hao Zhu; Ze Yu Zhang; Ji Yu Tao; Kai Zhao; Teck Peng Loh

doi:10.1021/acs.orglett.9b02361

Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Tong Hao Zhu, Ze Yu Zhang, Ji Yu Tao, Kai Zhao^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

Original language	English
Pages (from-to)	6155-6159
Number of pages	5
Journal	Organic Letters
Volume	21
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.9b02361
Publication status	Published - Aug 2 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2019 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.9b02361

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abstract = "A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.",

author = "Zhu, {Tong Hao} and Zhang, {Ze Yu} and Tao, {Ji Yu} and Kai Zhao and Loh, {Teck Peng}",

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AU - Tao, Ji Yu

AU - Zhao, Kai

AU - Loh, Teck Peng

PY - 2019/8/2

Y1 - 2019/8/2

N2 - A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

AB - A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield.

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Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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