Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

Yao Ding; Shen Yuan Zhang; Yu Chen Chen; Shuai Xin Fan; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.9b00697

Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

Yao Ding, Shen Yuan Zhang, Yu Chen Chen, Shuai Xin Fan, Jie Sheng Tian^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.

Original language	English
Pages (from-to)	2736-2739
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	8
DOIs	https://doi.org/10.1021/acs.orglett.9b00697
Publication status	Published - Apr 19 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2019 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.",

author = "Yao Ding and Zhang, {Shen Yuan} and Chen, {Yu Chen} and Fan, {Shuai Xin} and Tian, {Jie Sheng} and Loh, {Teck Peng}",

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AU - Ding, Yao

AU - Zhang, Shen Yuan

AU - Chen, Yu Chen

AU - Fan, Shuai Xin

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2019/4/19

Y1 - 2019/4/19

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AB - A nondirected amidation reaction of aromatic C-H bond was developed under iron(II) catalysis, using sulfonyl azides as the nitrogen source. The reaction displayed a broad substrate scope and good regioselectivities in the aspects of aromatic ring vs alkyl chain and different aromatic position of (alkyl)arenes. This method provided a new protocol for the synthesis of some aromatic amines, which were hard to achieve in a previous report.

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Regioselective C-H Amidation of (Alkyl)arenes by Iron(II) Catalysis

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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