Abstract
BAT (brown adipose tissue) is specialized to burn fatty acids for heat generation and energy expenditure to defend against cold and obesity. Accumulating studies have demonstrated that manipulation of BAT activity through various strategies can regulate metabolic homoeostasis and lead to a healthy phenotype. Two classes of ncRNA (non-coding RNA), miRNA and lncRNA (long non-coding RNA), play crucial roles in gene regulation during tissue development and remodelling. In the present review, we summarize recent findings on regulatory role of distinct ncRNAs in brown/beige adipocytes, and discuss how these ncRNA regulatory networks contribute to brown/beige fat development, differentiation and function. We suggest that targeting ncRNAs could be an attractive approach to enhance BAT activity for protecting the body against obesity and its pathological consequences.
| Original language | English |
|---|---|
| Journal | Bioscience Reports |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Aug 17 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 Authors.
ASJC Scopus Subject Areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
Keywords
- brown/beige adipocyte
- lncRNA
- miRNA
- obesity
