Relative reactivity of the dinuclear ruthenium complex [CpRu(CO)2]2 with diphenylselenyl sulphide and diphenyl disulphide

Wei Xiang Koh; Andrea Paris Gomez; Jiawen Lee; Jasmaadiyah Binte Habib Mohameed; Weng Kee Leong

doi:10.1016/j.rechem.2021.100159

Relative reactivity of the dinuclear ruthenium complex [CpRu(CO)₂]₂ with diphenylselenyl sulphide and diphenyl disulphide

Wei Xiang Koh, Andrea Paris Gomez, Jiawen Lee, Jasmaadiyah Binte Habib Mohameed, Weng Kee Leong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The reaction of the diruthenium complex [CpRu(CO)₂]₂ with the diphenyl dichalcogenides was found to proceed through photoinitiation to the [CpRu(CO)₂][rad] radical. Reaction with selenyl sulphide was slower than with disulphide, which has implications for the selective targeting of the enzyme thioredoxin reductase.

Original language	English
Article number	100159
Journal	Results in Chemistry
Volume	3
DOIs	https://doi.org/10.1016/j.rechem.2021.100159
Publication status	Published - Jan 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

ASJC Scopus Subject Areas

General Chemistry

Keywords

Dichalcogenides
Kinetics
Radical
Ruthenium
S-S bond
Se-S bond
Thioredoxin reductase

Access to Document

10.1016/j.rechem.2021.100159

Cite this

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title = "Relative reactivity of the dinuclear ruthenium complex [CpRu(CO)2]2 with diphenylselenyl sulphide and diphenyl disulphide",

abstract = "The reaction of the diruthenium complex [CpRu(CO)2]2 with the diphenyl dichalcogenides was found to proceed through photoinitiation to the [CpRu(CO)2][rad] radical. Reaction with selenyl sulphide was slower than with disulphide, which has implications for the selective targeting of the enzyme thioredoxin reductase.",

keywords = "Dichalcogenides, Kinetics, Radical, Ruthenium, S-S bond, Se-S bond, Thioredoxin reductase",

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AU - Gomez, Andrea Paris

AU - Lee, Jiawen

AU - Mohameed, Jasmaadiyah Binte Habib

AU - Leong, Weng Kee

PY - 2021/1

Y1 - 2021/1

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AB - The reaction of the diruthenium complex [CpRu(CO)2]2 with the diphenyl dichalcogenides was found to proceed through photoinitiation to the [CpRu(CO)2][rad] radical. Reaction with selenyl sulphide was slower than with disulphide, which has implications for the selective targeting of the enzyme thioredoxin reductase.

KW - Dichalcogenides

KW - Kinetics

KW - Radical

KW - Ruthenium

KW - S-S bond

KW - Se-S bond

KW - Thioredoxin reductase

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