Retinal oxygen extraction in humans

René M. Werkmeister; Doreen Schmidl; Gerold Aschinger; Veronika Doblhoff-Dier; Stefan Palkovits; Magdalena Wirth; Gerhard Garhöfer; Robert A. Linsenmeier; Rainer A. Leitgeb; Leopold Schmetterer

doi:10.1038/srep15763

Retinal oxygen extraction in humans

René M. Werkmeister, Doreen Schmidl, Gerold Aschinger, Veronika Doblhoff-Dier, Stefan Palkovits, Magdalena Wirth, Gerhard Garhöfer, Robert A. Linsenmeier, Rainer A. Leitgeb, Leopold Schmetterer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

Original language	English
Article number	15763
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep15763
Publication status	Published - Oct 27 2015
Externally published	Yes

ASJC Scopus Subject Areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/srep15763

Cite this

@article{e34a3299d2d04c7f94c294a385b4454c,

title = "Retinal oxygen extraction in humans",

abstract = "Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.",

author = "Werkmeister, {Ren{\'e} M.} and Doreen Schmidl and Gerold Aschinger and Veronika Doblhoff-Dier and Stefan Palkovits and Magdalena Wirth and Gerhard Garh{\"o}fer and Linsenmeier, {Robert A.} and Leitgeb, {Rainer A.} and Leopold Schmetterer",

year = "2015",

month = oct,

day = "27",

doi = "10.1038/srep15763",

language = "English",

volume = "5",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Retinal oxygen extraction in humans

AU - Werkmeister, René M.

AU - Schmidl, Doreen

AU - Aschinger, Gerold

AU - Doblhoff-Dier, Veronika

AU - Palkovits, Stefan

AU - Wirth, Magdalena

AU - Garhöfer, Gerhard

AU - Linsenmeier, Robert A.

AU - Leitgeb, Rainer A.

AU - Schmetterer, Leopold

PY - 2015/10/27

Y1 - 2015/10/27

N2 - Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

AB - Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O 2)/min to 0.88 ± 0.14 μl(O 2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.

UR - http://www.scopus.com/inward/record.url?scp=84946078381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946078381&partnerID=8YFLogxK

U2 - 10.1038/srep15763

DO - 10.1038/srep15763

M3 - Article

C2 - 26503332

AN - SCOPUS:84946078381

SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 15763

ER -

Retinal oxygen extraction in humans

Abstract

ASJC Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this