Rhodium(III)-catalyzed directed C-H benzylation and allylation of indoles with organosilicon reagents

Ming Zhu Lu; Cheng Qiang Wang; Sheng Jin Song; Teck Peng Loh

doi:10.1039/c6qo00589f

Rhodium(III)-catalyzed directed C-H benzylation and allylation of indoles with organosilicon reagents

Ming Zhu Lu, Cheng Qiang Wang, Sheng Jin Song, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Rhodium(iii)-catalyzed C2-benzylation and allylation of indoles with organosilicon reagents via chelation-assisted C-H activation has been developed. This protocol demonstrates a board substrate scope, tolerates a broad range of synthetically useful functional groups, and enables a straightforward route to C2-benzyl- and allylindole derivatives.

Original language	English
Pages (from-to)	303-307
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	4
Issue number	2
DOIs	https://doi.org/10.1039/c6qo00589f
Publication status	Published - Feb 2017
Externally published	Yes

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Publisher Copyright:
© the Partner Organisations 2017.

ASJC Scopus Subject Areas

Organic Chemistry

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abstract = "Rhodium(iii)-catalyzed C2-benzylation and allylation of indoles with organosilicon reagents via chelation-assisted C-H activation has been developed. This protocol demonstrates a board substrate scope, tolerates a broad range of synthetically useful functional groups, and enables a straightforward route to C2-benzyl- and allylindole derivatives.",

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AB - Rhodium(iii)-catalyzed C2-benzylation and allylation of indoles with organosilicon reagents via chelation-assisted C-H activation has been developed. This protocol demonstrates a board substrate scope, tolerates a broad range of synthetically useful functional groups, and enables a straightforward route to C2-benzyl- and allylindole derivatives.

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Rhodium(III)-catalyzed directed C-H benzylation and allylation of indoles with organosilicon reagents

Abstract

Bibliographical note

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