RNA interference in glial cells for nerve injury treatment

Junquan Lin; Seung Bin Jo; Tae Hyun Kim; Hae Won Kim; Sing Yian Chew

doi:10.1177/2041731420939224

RNA interference in glial cells for nerve injury treatment

Junquan Lin, Seung Bin Jo, Tae Hyun Kim, Hae Won Kim, Sing Yian Chew^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

Original language	English
Journal	Journal of Tissue Engineering
Volume	11
DOIs	https://doi.org/10.1177/2041731420939224
Publication status	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

ASJC Scopus Subject Areas

Medicine (miscellaneous)
Biomaterials
Biomedical Engineering

Keywords

central nervous system
drug delivery
nerve injury
RNA interference

Access to Document

10.1177/2041731420939224

Cite this

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AU - Lin, Junquan

AU - Jo, Seung Bin

AU - Kim, Tae Hyun

AU - Kim, Hae Won

AU - Chew, Sing Yian

N1 - Publisher Copyright: © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

AB - Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

KW - central nervous system

KW - drug delivery

KW - nerve injury

KW - RNA interference

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RNA interference in glial cells for nerve injury treatment

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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