Ruthenium-Based Structural Mimics of the Cofactor of [Fe]-Hydrogenase: Replacement of the Acyl Moiety with an N-Heterocyclic Carbene

Chandan Kr Barik; Xian Qi Chan; Han Vinh Huynh; Yongxin Li; Rakesh Ganguly; Weng Kee Leong

doi:10.1002/slct.202002889

Ruthenium-Based Structural Mimics of the Cofactor of [Fe]-Hydrogenase: Replacement of the Acyl Moiety with an N-Heterocyclic Carbene

Chandan Kr Barik, Xian Qi Chan, Han Vinh Huynh, Yongxin Li, Rakesh Ganguly, Weng Kee Leong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A synthetic route is reported towards ruthenium-based structural mimics of the [Fe]-hydrogenase metal cofactor in which the acyl moiety is replaced by an N-heterocyclic carbene. It is observed that the pyridyl-NHC ligand has a rather different trans influence from that of a simple NHC in their ruthenium derivatives. The basis for this difference is explored crystallographically and computationally, and it accounts for their different behaviour towards thiolation.

Original language	English
Pages (from-to)	10775-10780
Number of pages	6
Journal	ChemistrySelect
Volume	5
Issue number	34
DOIs	https://doi.org/10.1002/slct.202002889
Publication status	Published - Sept 14 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Wiley-VCH GmbH

ASJC Scopus Subject Areas

General Chemistry

Keywords

N-heterocyclic carbene
Ruthenium
trans effect
[Fe]-hydrogenase

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10.1002/slct.202002889

Cite this

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abstract = "A synthetic route is reported towards ruthenium-based structural mimics of the [Fe]-hydrogenase metal cofactor in which the acyl moiety is replaced by an N-heterocyclic carbene. It is observed that the pyridyl-NHC ligand has a rather different trans influence from that of a simple NHC in their ruthenium derivatives. The basis for this difference is explored crystallographically and computationally, and it accounts for their different behaviour towards thiolation.",

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AU - Chan, Xian Qi

AU - Huynh, Han Vinh

AU - Li, Yongxin

AU - Ganguly, Rakesh

AU - Leong, Weng Kee

PY - 2020/9/14

Y1 - 2020/9/14

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AB - A synthetic route is reported towards ruthenium-based structural mimics of the [Fe]-hydrogenase metal cofactor in which the acyl moiety is replaced by an N-heterocyclic carbene. It is observed that the pyridyl-NHC ligand has a rather different trans influence from that of a simple NHC in their ruthenium derivatives. The basis for this difference is explored crystallographically and computationally, and it accounts for their different behaviour towards thiolation.

KW - N-heterocyclic carbene

KW - Ruthenium

KW - trans effect

KW - [Fe]-hydrogenase

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Ruthenium-Based Structural Mimics of the Cofactor of [Fe]-Hydrogenase: Replacement of the Acyl Moiety with an N-Heterocyclic Carbene

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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