Abstract
Although stem cell therapy holds tremendous promise in tissue regeneration and disease treatment, its full potential may only be realized through the thorough understanding and capability in specifically directing stem cell fate commitment. A scaffold-based approach of imparting physical and biochemical cues appears to be a logical method in reconstructing the complex three-dimensional configuration of stem cell niches. In fact, interest in this area has gained significant momentum over the recent years. This review summarizes and evaluates the recent outcomes of studies associated with a scaffold-based approach to directing and understanding stem cell neural and cardiovascular differentiation.
Original language | English |
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Pages (from-to) | 355-374 |
Number of pages | 20 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 97 A |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 1 2011 |
Externally published | Yes |
ASJC Scopus Subject Areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys
Keywords
- contact guidance
- matrix compliance
- stem cell fate
- sustained release
- topography