Scaffold-based approach to direct stem cell neural and cardiovascular differentiation: An analysis of physical and biochemical effects

Sing Yian Chew, Wei Ching Low

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

Although stem cell therapy holds tremendous promise in tissue regeneration and disease treatment, its full potential may only be realized through the thorough understanding and capability in specifically directing stem cell fate commitment. A scaffold-based approach of imparting physical and biochemical cues appears to be a logical method in reconstructing the complex three-dimensional configuration of stem cell niches. In fact, interest in this area has gained significant momentum over the recent years. This review summarizes and evaluates the recent outcomes of studies associated with a scaffold-based approach to directing and understanding stem cell neural and cardiovascular differentiation.

Original languageEnglish
Pages (from-to)355-374
Number of pages20
JournalJournal of Biomedical Materials Research - Part A
Volume97 A
Issue number3
DOIs
Publication statusPublished - Jun 1 2011
Externally publishedYes

ASJC Scopus Subject Areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Keywords

  • contact guidance
  • matrix compliance
  • stem cell fate
  • sustained release
  • topography

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