Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Ulla Milbreta; Junquan Lin; Coline Pinese; William Ong; Jiah Shin Chin; Hitomi Shirahama; Ruifa Mi; Anna Williams; Marie E. Bechler; Jun Wang; Charles ffrench-Constant; Ahmet Hoke; Sing Yian Chew

doi:10.1016/j.ymthe.2018.11.016

Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Ulla Milbreta, Junquan Lin, Coline Pinese, William Ong, Jiah Shin Chin, Hitomi Shirahama, Ruifa Mi, Anna Williams, Marie E. Bechler, Jun Wang, Charles ffrench-Constant, Ahmet Hoke, Sing Yian Chew^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.

Original language	English
Pages (from-to)	411-423
Number of pages	13
Journal	Molecular Therapy
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.ymthe.2018.11.016
Publication status	Published - Feb 6 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 The American Society of Gene and Cell Therapy

ASJC Scopus Subject Areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

Keywords

CNS
electrospinning
gene silencing
microRNA
myelination
non-viral
oligodendrocytes
regeneration
scaffold
sustained

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10.1016/j.ymthe.2018.11.016

Cite this

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title = "Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination",

abstract = "Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.",

keywords = "CNS, electrospinning, gene silencing, microRNA, myelination, non-viral, oligodendrocytes, regeneration, scaffold, sustained",

author = "Ulla Milbreta and Junquan Lin and Coline Pinese and William Ong and Chin, \{Jiah Shin\} and Hitomi Shirahama and Ruifa Mi and Anna Williams and Bechler, \{Marie E.\} and Jun Wang and Charles ffrench-Constant and Ahmet Hoke and Chew, \{Sing Yian\}",

note = "Publisher Copyright: {\textcopyright} 2018 The American Society of Gene and Cell Therapy",

year = "2019",

month = feb,

day = "6",

doi = "10.1016/j.ymthe.2018.11.016",

language = "English",

volume = "27",

pages = "411--423",

journal = "Molecular Therapy",

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TY - JOUR

T1 - Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

AU - Milbreta, Ulla

AU - Lin, Junquan

AU - Pinese, Coline

AU - Ong, William

AU - Chin, Jiah Shin

AU - Shirahama, Hitomi

AU - Mi, Ruifa

AU - Williams, Anna

AU - Bechler, Marie E.

AU - Wang, Jun

AU - ffrench-Constant, Charles

AU - Hoke, Ahmet

AU - Chew, Sing Yian

PY - 2019/2/6

Y1 - 2019/2/6

N2 - Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.

AB - Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.

KW - CNS

KW - electrospinning

KW - gene silencing

KW - microRNA

KW - myelination

KW - non-viral

KW - oligodendrocytes

KW - regeneration

KW - scaffold

KW - sustained

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DO - 10.1016/j.ymthe.2018.11.016

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SN - 1525-0016

VL - 27

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EP - 423

JO - Molecular Therapy

JF - Molecular Therapy

IS - 2

ER -

Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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