Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

Jingchao Li; Chen Xie; Jiaguo Huang; Yuyan Jiang; Qingqing Miao; Kanyi Pu

doi:10.1002/anie.201800511

Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

Jingchao Li, Chen Xie, Jiaguo Huang, Yuyan Jiang, Qingqing Miao, Kanyi Pu^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

259 Citations (Scopus)

Abstract

Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.

Original language	English
Pages (from-to)	3995-3998
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	15
DOIs	https://doi.org/10.1002/anie.201800511
Publication status	Published - Apr 3 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

cancer therapy
photothermal therapy
polymer nanoparticles
protein activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201800511

Cite this

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abstract = "Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.",

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AU - Li, Jingchao

AU - Xie, Chen

AU - Huang, Jiaguo

AU - Jiang, Yuyan

AU - Miao, Qingqing

AU - Pu, Kanyi

PY - 2018/4/3

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AB - Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.

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KW - photothermal therapy

KW - polymer nanoparticles

KW - protein activity

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Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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