Sensing of dangerous DNA

Stephan Gasser; Wendy Y.L. Zhang; Nikki Yi Jie Tan; Shubhita Tripathi; Manuel A. Suter; Zhi Huan Chew; Muznah Khatoo; Joanne Ngeow; Florence S.G. Cheung

doi:10.1016/j.mad.2016.09.001

Sensing of dangerous DNA

Stephan Gasser^*, Wendy Y.L. Zhang, Nikki Yi Jie Tan, Shubhita Tripathi, Manuel A. Suter, Zhi Huan Chew, Muznah Khatoo, Joanne Ngeow, Florence S.G. Cheung

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.

Original language	English
Pages (from-to)	33-46
Number of pages	14
Journal	Mechanisms of Ageing and Development
Volume	165
DOIs	https://doi.org/10.1016/j.mad.2016.09.001
Publication status	Published - Jul 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ireland Ltd

ASJC Scopus Subject Areas

Ageing
Developmental Biology

Keywords

Cancer
Cytosolic DNA
DNA repair
DNA sensor
Innate immunity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mad.2016.09.001

Cite this

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title = "Sensing of dangerous DNA",

abstract = "The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.",

keywords = "Cancer, Cytosolic DNA, DNA repair, DNA sensor, Innate immunity",

author = "Stephan Gasser and Zhang, {Wendy Y.L.} and Tan, {Nikki Yi Jie} and Shubhita Tripathi and Suter, {Manuel A.} and Chew, {Zhi Huan} and Muznah Khatoo and Joanne Ngeow and Cheung, {Florence S.G.}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd",

year = "2017",

month = jul,

doi = "10.1016/j.mad.2016.09.001",

language = "English",

volume = "165",

pages = "33--46",

journal = "Mechanisms of Ageing and Development",

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TY - JOUR

T1 - Sensing of dangerous DNA

AU - Gasser, Stephan

AU - Zhang, Wendy Y.L.

AU - Tan, Nikki Yi Jie

AU - Tripathi, Shubhita

AU - Suter, Manuel A.

AU - Chew, Zhi Huan

AU - Khatoo, Muznah

AU - Ngeow, Joanne

AU - Cheung, Florence S.G.

PY - 2017/7

Y1 - 2017/7

N2 - The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.

AB - The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.

KW - Cancer

KW - Cytosolic DNA

KW - DNA repair

KW - DNA sensor

KW - Innate immunity

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U2 - 10.1016/j.mad.2016.09.001

DO - 10.1016/j.mad.2016.09.001

M3 - Review article

C2 - 27614000

AN - SCOPUS:84994882445

SN - 0047-6374

VL - 165

SP - 33

EP - 46

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

ER -

Sensing of dangerous DNA

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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