Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Zhenpeng Qin; Warren C.W. Chan; David R. Boulware; Taner Akkin; Elissa K. Butler; John C. Bischof

doi:10.1002/anie.201200997

Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Zhenpeng Qin^*, Warren C.W. Chan, David R. Boulware, Taner Akkin, Elissa K. Butler, John C. Bischof

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

179 Citations (Scopus)

Abstract

Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).

Original language	English
Pages (from-to)	4358-4361
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	18
DOIs	https://doi.org/10.1002/anie.201200997
Publication status	Published - Apr 27 2012
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

biosensors
diagnostics
immunoassays
nanoparticles
thermal contrast

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10.1002/anie.201200997

Cite this

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abstract = "Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).",

keywords = "biosensors, diagnostics, immunoassays, nanoparticles, thermal contrast",

author = "Zhenpeng Qin and Chan, {Warren C.W.} and Boulware, {David R.} and Taner Akkin and Butler, {Elissa K.} and Bischof, {John C.}",

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AU - Qin, Zhenpeng

AU - Chan, Warren C.W.

AU - Boulware, David R.

AU - Akkin, Taner

AU - Butler, Elissa K.

AU - Bischof, John C.

PY - 2012/4/27

Y1 - 2012/4/27

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AB - Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).

KW - biosensors

KW - diagnostics

KW - immunoassays

KW - nanoparticles

KW - thermal contrast

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ER -

Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

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