Single-phase NaDyF4:Tb3+ nanocrystals as multifunctional contrast agents in high-field magnetic resonance and optical imaging

Yan Zhang; Vimalan Vijayaragavan; Gautom K. Das; Kishore K. Bhakoo; Timothy Thatt Yang Tan

doi:10.1002/ejic.201101203

Single-phase NaDyF₄:Tb³⁺ nanocrystals as multifunctional contrast agents in high-field magnetic resonance and optical imaging

Yan Zhang, Vimalan Vijayaragavan, Gautom K. Das, Kishore K. Bhakoo^*, Timothy Thatt Yang Tan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The current work reports single-phase, terbium-doped sodium dysprosium fluoride (NaDyF₄:Tb³⁺) nanocrystals with green luminescence and good T₂ contrast in 7.0-T MRI phantom and animal imaging. The current nanocrystals demonstrate good potential as a dual modal contrast agent for high-field magnetic resonance (MR) and fluorescence imaging. Dual-mode NaDyF₄:Tb³⁺ nanocrystals were synthesized by the thermal decomposition method. The nanocrystals showedgreen fluorescence and good negative T₂ contrast in 7-T MR phantom and animal imaging.

Original language	English
Pages (from-to)	2044-2048
Number of pages	5
Journal	European Journal of Inorganic Chemistry
Issue number	12
DOIs	https://doi.org/10.1002/ejic.201101203
Publication status	Published - Apr 2012
Externally published	Yes

ASJC Scopus Subject Areas

Inorganic Chemistry

Keywords

Doping
Dysprosium
Fluorescence
Imaging agents
Nanoparticles

Access to Document

10.1002/ejic.201101203

Cite this

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title = "Single-phase NaDyF4:Tb3+ nanocrystals as multifunctional contrast agents in high-field magnetic resonance and optical imaging",

abstract = "The current work reports single-phase, terbium-doped sodium dysprosium fluoride (NaDyF4:Tb3+) nanocrystals with green luminescence and good T2 contrast in 7.0-T MRI phantom and animal imaging. The current nanocrystals demonstrate good potential as a dual modal contrast agent for high-field magnetic resonance (MR) and fluorescence imaging. Dual-mode NaDyF4:Tb3+ nanocrystals were synthesized by the thermal decomposition method. The nanocrystals showedgreen fluorescence and good negative T2 contrast in 7-T MR phantom and animal imaging.",

keywords = "Doping, Dysprosium, Fluorescence, Imaging agents, Nanoparticles",

author = "Yan Zhang and Vimalan Vijayaragavan and Das, {Gautom K.} and Bhakoo, {Kishore K.} and Tan, {Timothy Thatt Yang}",

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AU - Zhang, Yan

AU - Vijayaragavan, Vimalan

AU - Das, Gautom K.

AU - Bhakoo, Kishore K.

AU - Tan, Timothy Thatt Yang

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AB - The current work reports single-phase, terbium-doped sodium dysprosium fluoride (NaDyF4:Tb3+) nanocrystals with green luminescence and good T2 contrast in 7.0-T MRI phantom and animal imaging. The current nanocrystals demonstrate good potential as a dual modal contrast agent for high-field magnetic resonance (MR) and fluorescence imaging. Dual-mode NaDyF4:Tb3+ nanocrystals were synthesized by the thermal decomposition method. The nanocrystals showedgreen fluorescence and good negative T2 contrast in 7-T MR phantom and animal imaging.

KW - Doping

KW - Dysprosium

KW - Fluorescence

KW - Imaging agents

KW - Nanoparticles

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