@inproceedings{20e64dd3d68642a09c42c087314ec749,
title = "Single-step isolation of microparticles from whole blood for rapid vascular health profiling in diabetes mellitus",
abstract = "Cell-derived microparticles (MPs) in blood are widely proposed as surrogate biomarkers in disease and health monitoring. Herein, we describe a novel inertial microfluidic technology termed as High-resolution Dean Flow Fractionation (HiDFF), to isolate MPs from whole blood directly for vascular health profiling. Clinical utility was demonstrated by rapid MPs isolation and flow cytometry characterization of healthy subjects and type 2 diabetes mellitus (T2DM) patients. Higher endothelialand neutrophil-derived MP were observed in T2DM patients, indicating elevated vascular inflammation and pro-inflammation states. Our results suggest MPs as novel cell-based biomarkers for vascular health point-of-care monitoring and risk stratification in T2DM patients.",
keywords = "Blood, Diabetes, Inertial microfluidics, Microparticles",
author = "Tay, {Hui Min} and Chen, {Zhijie Joshua} and Rinkoo Dalan and Loo, {Say Chye Joachim} and Boehm, {Bernhard O.} and Hou, {Han Wei}",
year = "2016",
language = "English",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "323--324",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
note = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
}
