Single-walled carbon nanotube based real-time organophosphate detector

Ningyi Liu; Xianpeng Cai; Yu Lei; Qing Zhang; Mary B. Chan-Park; Changming Li; Wilfred Chen; Ashok Mulchandani

doi:10.1002/elan.200603761

Single-walled carbon nanotube based real-time organophosphate detector

Ningyi Liu^*, Xianpeng Cai, Yu Lei, Qing Zhang, Mary B. Chan-Park, Changming Li, Wilfred Chen, Ashok Mulchandani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A novel single-walled carbon nanotube (SWNT) based biosensor for real-time detection of organophosphate has been developed. Horizontally aligned SWNTs are assembled to desirable electrodes using AC dielectrophoresis technique. Organophosphorus hydrolase (OPH) immobilized on the SWNTs by nonspecific binding triggers enzymatic hydrolysis of organophosphates (OPs), such as paraoxon, consequently causing a detectable change in the conductance of the SWNTs. The conductance change is found to be correlated to the concentration of organophosphate. Our results suggest the novel biosensor has great potential to serve as a simple and reusable platform of sensing organophosphate on a real-time basis.

Original language	English
Pages (from-to)	616-619
Number of pages	4
Journal	Electroanalysis
Volume	19
Issue number	5
DOIs	https://doi.org/10.1002/elan.200603761
Publication status	Published - Mar 2007
Externally published	Yes

ASJC Scopus Subject Areas

Analytical Chemistry
Electrochemistry

Keywords

Bioelectronics
Biosensor
Carbon nanotubes
Organophosphorus hydrolase
Real-time

Access to Document

10.1002/elan.200603761

Cite this

@article{9680dff376cb416aa340ac45f5b30080,

title = "Single-walled carbon nanotube based real-time organophosphate detector",

abstract = "A novel single-walled carbon nanotube (SWNT) based biosensor for real-time detection of organophosphate has been developed. Horizontally aligned SWNTs are assembled to desirable electrodes using AC dielectrophoresis technique. Organophosphorus hydrolase (OPH) immobilized on the SWNTs by nonspecific binding triggers enzymatic hydrolysis of organophosphates (OPs), such as paraoxon, consequently causing a detectable change in the conductance of the SWNTs. The conductance change is found to be correlated to the concentration of organophosphate. Our results suggest the novel biosensor has great potential to serve as a simple and reusable platform of sensing organophosphate on a real-time basis.",

keywords = "Bioelectronics, Biosensor, Carbon nanotubes, Organophosphorus hydrolase, Real-time",

author = "Ningyi Liu and Xianpeng Cai and Yu Lei and Qing Zhang and Chan-Park, {Mary B.} and Changming Li and Wilfred Chen and Ashok Mulchandani",

year = "2007",

month = mar,

doi = "10.1002/elan.200603761",

language = "English",

volume = "19",

pages = "616--619",

journal = "Electroanalysis",

issn = "1040-0397",

publisher = "Wiley-VCH Verlag",

number = "5",

}

TY - JOUR

T1 - Single-walled carbon nanotube based real-time organophosphate detector

AU - Liu, Ningyi

AU - Cai, Xianpeng

AU - Lei, Yu

AU - Zhang, Qing

AU - Chan-Park, Mary B.

AU - Li, Changming

AU - Chen, Wilfred

AU - Mulchandani, Ashok

PY - 2007/3

Y1 - 2007/3

N2 - A novel single-walled carbon nanotube (SWNT) based biosensor for real-time detection of organophosphate has been developed. Horizontally aligned SWNTs are assembled to desirable electrodes using AC dielectrophoresis technique. Organophosphorus hydrolase (OPH) immobilized on the SWNTs by nonspecific binding triggers enzymatic hydrolysis of organophosphates (OPs), such as paraoxon, consequently causing a detectable change in the conductance of the SWNTs. The conductance change is found to be correlated to the concentration of organophosphate. Our results suggest the novel biosensor has great potential to serve as a simple and reusable platform of sensing organophosphate on a real-time basis.

AB - A novel single-walled carbon nanotube (SWNT) based biosensor for real-time detection of organophosphate has been developed. Horizontally aligned SWNTs are assembled to desirable electrodes using AC dielectrophoresis technique. Organophosphorus hydrolase (OPH) immobilized on the SWNTs by nonspecific binding triggers enzymatic hydrolysis of organophosphates (OPs), such as paraoxon, consequently causing a detectable change in the conductance of the SWNTs. The conductance change is found to be correlated to the concentration of organophosphate. Our results suggest the novel biosensor has great potential to serve as a simple and reusable platform of sensing organophosphate on a real-time basis.

KW - Bioelectronics

KW - Biosensor

KW - Carbon nanotubes

KW - Organophosphorus hydrolase

KW - Real-time

UR - http://www.scopus.com/inward/record.url?scp=34547641929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547641929&partnerID=8YFLogxK

U2 - 10.1002/elan.200603761

DO - 10.1002/elan.200603761

M3 - Article

AN - SCOPUS:34547641929

SN - 1040-0397

VL - 19

SP - 616

EP - 619

JO - Electroanalysis

JF - Electroanalysis

IS - 5

ER -

Single-walled carbon nanotube based real-time organophosphate detector

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this