Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity

Sijing Xiong; Yuxin Tang; Huiyun Sheena Ng; Xinxin Zhao; Zhelong Jiang; Zhong Chen; Kee Woei Ng; Say Chye Joachim Loo

doi:10.1016/j.tox.2012.12.015

Specific surface area of titanium dioxide (TiO₂) particles influences cyto- and photo-toxicity

Sijing Xiong, Yuxin Tang, Huiyun Sheena Ng, Xinxin Zhao, Zhelong Jiang, Zhong Chen, Kee Woei Ng, Say Chye Joachim Loo^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO₂) particles could influence both cytotoxicity and phototoxicity. TiO₂ particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO₂ particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24h incubation. The observed cytotoxicity from TiO₂ particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO₂ particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO₂ particles with extracellular proteins were found to decrease toxicity effects.

Original language	English
Pages (from-to)	132-140
Number of pages	9
Journal	Toxicology
Volume	304
DOIs	https://doi.org/10.1016/j.tox.2012.12.015
Publication status	Published - Feb 8 2013
Externally published	Yes

ASJC Scopus Subject Areas

Toxicology

Keywords

Cytotoxicity
Particles
Phototoxicity
Surface area
TiO

Access to Document

10.1016/j.tox.2012.12.015

Cite this

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title = "Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity",

abstract = "The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects.",

keywords = "Cytotoxicity, Particles, Phototoxicity, Surface area, TiO",

author = "Sijing Xiong and Yuxin Tang and Ng, {Huiyun Sheena} and Xinxin Zhao and Zhelong Jiang and Zhong Chen and Ng, {Kee Woei} and Loo, {Say Chye Joachim}",

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AU - Ng, Huiyun Sheena

AU - Zhao, Xinxin

AU - Jiang, Zhelong

AU - Chen, Zhong

AU - Ng, Kee Woei

AU - Loo, Say Chye Joachim

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