Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle

P. R. Preiser; S. Khan; F. T.M. Costa; W. Jarra; E. Belnoue; S. Ogun; A. A. Holder; T. Voza; I. Landau; G. Snounou; L. Rénia

doi:10.1126/science.1064938

Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle

P. R. Preiser^*, S. Khan, F. T.M. Costa, W. Jarra, E. Belnoue, S. Ogun, A. A. Holder, T. Voza, I. Landau, G. Snounou, L. Rénia

^*Corresponding author for this work

Medical Research Council

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Members of a multigene family in the rodent malaria parasite Plasmodium yoelii yoelii code for 235-kilodalton proteins (Py235) that are located in the merozoite apical complex, are implicated in virulence, and may determine red blood cell specificity. We show that distinct subsets of py235 genes are expressed in sporozoites and hepatic and erythrocytic stages. Antibodies to Py235 inhibited sporozoite invasion of hepatocytes. The switch in expression profile occurred immediately after transition from one stage to another. The results suggest that this differential expression is driven by strong biological requirements and provide evidence that hepatic and erythrocytic merozoites differ.

Original language	English
Pages (from-to)	342-345
Number of pages	4
Journal	Science
Volume	295
Issue number	5553
DOIs	https://doi.org/10.1126/science.1064938
Publication status	Published - Jan 11 2002
Externally published	Yes

ASJC Scopus Subject Areas

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1064938

Cite this

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title = "Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle",

abstract = "Members of a multigene family in the rodent malaria parasite Plasmodium yoelii yoelii code for 235-kilodalton proteins (Py235) that are located in the merozoite apical complex, are implicated in virulence, and may determine red blood cell specificity. We show that distinct subsets of py235 genes are expressed in sporozoites and hepatic and erythrocytic stages. Antibodies to Py235 inhibited sporozoite invasion of hepatocytes. The switch in expression profile occurred immediately after transition from one stage to another. The results suggest that this differential expression is driven by strong biological requirements and provide evidence that hepatic and erythrocytic merozoites differ.",

author = "Preiser, {P. R.} and S. Khan and Costa, {F. T.M.} and W. Jarra and E. Belnoue and S. Ogun and Holder, {A. A.} and T. Voza and I. Landau and G. Snounou and L. R{\'e}nia",

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doi = "10.1126/science.1064938",

language = "English",

volume = "295",

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T1 - Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle

AU - Preiser, P. R.

AU - Khan, S.

AU - Costa, F. T.M.

AU - Jarra, W.

AU - Belnoue, E.

AU - Ogun, S.

AU - Holder, A. A.

AU - Voza, T.

AU - Landau, I.

AU - Snounou, G.

AU - Rénia, L.

PY - 2002/1/11

Y1 - 2002/1/11

N2 - Members of a multigene family in the rodent malaria parasite Plasmodium yoelii yoelii code for 235-kilodalton proteins (Py235) that are located in the merozoite apical complex, are implicated in virulence, and may determine red blood cell specificity. We show that distinct subsets of py235 genes are expressed in sporozoites and hepatic and erythrocytic stages. Antibodies to Py235 inhibited sporozoite invasion of hepatocytes. The switch in expression profile occurred immediately after transition from one stage to another. The results suggest that this differential expression is driven by strong biological requirements and provide evidence that hepatic and erythrocytic merozoites differ.

AB - Members of a multigene family in the rodent malaria parasite Plasmodium yoelii yoelii code for 235-kilodalton proteins (Py235) that are located in the merozoite apical complex, are implicated in virulence, and may determine red blood cell specificity. We show that distinct subsets of py235 genes are expressed in sporozoites and hepatic and erythrocytic stages. Antibodies to Py235 inhibited sporozoite invasion of hepatocytes. The switch in expression profile occurred immediately after transition from one stage to another. The results suggest that this differential expression is driven by strong biological requirements and provide evidence that hepatic and erythrocytic merozoites differ.

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DO - 10.1126/science.1064938

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JO - Science

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Stage-specific transcription of distinct repertoires of a multigene family during Plasmodium life cycle

Abstract

ASJC Scopus Subject Areas

UN SDGs

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